ArticleBrain communications2026
A vascular component to the selective vulnerability of the medial temporal lobe to tau pathology.
Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
The medial temporal lobe is widely recognized as an early site of pathological tau deposition, a central feature in the development of cognitive symptoms. As of now, the biological mechanisms underlying this selective vulnerability of the medial temporal lobe are not yet understood. Here, we tested whether alterations in medial temporal lobe arterial structure are associated with early tau accumulation and cognitive decline. We first applied a novel imaging methodology (super-selective arterial spin labelling) to map vascular supply to the medial temporal lobe. Next, we cross-sectionally investigated the relationship between medial temporal lobe artery diameters and tau burden, derived from magnetic resonance angiography and positron emission tomography imaging, in 151 cognitively unimpaired individuals (mean age: 67.6 years old). Finally, we examined whether artery diameter was correlated with the rate of cognitive decline in a separate cohort of 43 individuals (mean age: 74.2 years old). We found that the blood supply to the medial temporal lobe depended more on arteries from the anterior circulation than the posterior circulation. Individuals with small anterior choroidal artery diameters tended to show higher medial temporal lobe tau burden (r = -0.26,
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