ArticleIranian journal of basic medical sciences2026
Radiotherapy-associated changes in the miR-124/SP1 axis in a rat glioma model.
Article in Iranian journal of basic medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objectives: Glioma is an aggressive brain tumor that frequently involves microRNA dysregulation. Rno-miR-124-3p is a brain-enriched miRNA involved in gene regulation, with Specificity Protein 1 (SP1) as its validated target. Radiotherapy remains a cornerstone of glioma treatment; however, its molecular effects on miRNA-transcription factor axes are not fully understood. We hypothesized that radiotherapy up-regulates Rno-miR-124-3p, thereby down-regulating SP1. Accordingly, this study evaluated their expression following radiotherapy in a rat glioma model. Materials and Methods: C6 glioma cells were cultured, and an effective radiation dose was determined using an MTT assay. Sixty male Wistar rats were randomly assigned to six experimental groups: control, sham, glioma, and their corresponding radiotherapy-treated groups. Glioma was induced by stereotactic injection of C6 cells into the striatum. After radiotherapy, brain tissue was collected for histological and molecular analyses. Tumor expression of Rno-miR-124-3p and SP1 was quantified by real-time PCR. Results: In glioma-bearing rats, Rno-miR-124-3p expression was significantly down-regulated, whereas SP1 was significantly up-regulated compared with control groups ( Conclusion: Glioma development alters the Rno-miR-124-3p/SP1 regulatory axis. Radiotherapy modulates this molecular pattern, suggesting a potential role for Rno-miR-124-3p in glioma-related pathways. Further studies are needed to clarify its functional and clinical relevance.
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