ReviewHealth science reports2026
Effects of Drug Resistance on the Global Spread of Malaria: A Systematic Literature Review.
Review in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: Malaria remains a major health crisis in tropical regions, with Sub-Saharan Africa bearing the heaviest burden. While insecticide-treated nets and artemisinin-based combination therapies (ACTs) have reduced cases, emerging parasite resistance to artemisinin threatens these gains. This review synthesizes evidence on how drug resistance impacts malaria transmission and control globally. Methods: This systematic review followed PRISMA 2020 guidelines and was registered with PROSPERO (CRD420261336060). A comprehensive search of PubMed/MEDLINE, Embase, and Web of Science, supplemented by hand-searching and grey literature, identified studies published between January 2011 and December 2025. Of 897,299 initial records, 22 studies met the inclusion criteria after screening and quality assessment using JBI, the Newcastle-Ottawa Scale, and Cochrane RoB 2 tools. Data were summarized thematically; meta-analysis was not conducted due to heterogeneity and varying bias. Sensitivity analysis confirmed robustness. Results: Drug resistance reduces treatment effectiveness and increases transmission. Artemisinin resistance, primarily associated with Conclusion: Without urgent global collaboration, resistance will undermine malaria elimination and increase disease burden. This review calls attention to novel treatments, enhanced surveillance, and regionally tailored strategies to contain resistance and sustain malaria control efforts worldwide.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.