Evidence map›Paper›PMID 42677049›Full record

ArticleCentral-European journal of immunology2026

Musculin enhances the immune function of peritoneal macrophages in mice.

Yu Xia, Xin Zhang, Jing Yu, Guochang Liu, Daiqi Chen, Lu Kang, Yun Wang, Jun Yan

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In one paragraph

Article in Central-European journal of immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Yu XiaDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Xin ZhangDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Jing YuDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Guochang LiuDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Daiqi ChenDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Lu KangDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.
Yun WangDepartment of Cell Biology, College of Basic Medical Sciences, Army Medical University (Third Military Medical University), Chongqing, 400038, China.
Jun YanDepartment of Special War Wound, State Key Laboratory of Trauma and Chemical Poisoning, Research Institute of Surgery, Daping Hospital, Army Medical University (Third Military Medical University), Chongqing, 400042, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Macrophages play a key role in infection, and musculin (MSC) is closely associated with immune cells. The objective of this study was to investigate the effect of MSC on the immune function of mouse peritoneal macrophages. Material and methods: Peritoneal macrophages from wild-type (WT) and MSC knockout (MSC-/-) mice were obtained and cultured for 12 hours. The cells were subsequently treated with lipopolysaccharide (LPS). After 24 hours, the peritoneal macrophages and their supernatants were collected. The changes in the adhesion index in each group were then recorded by cell counting, and the phagocytic index and phagocytic rate were calculated via bacterial phagocytosis experiments. Additionally, the levels of interleukin (IL)-1 Results: At 24 hours after LPS treatment, the number of peritoneal macrophages in the MSC-/- group was lower than that in the WT group, while the adhesion index in the former group was higher than that in the latter group. Compared with those in the WT group, the phagocytosis index and phagocytosis rate were significantly lower in the MSC-/- group, while the levels of IL-1 Conclusions: Musculin may enhance the immune function of peritoneal macrophages in mice.

Indexed as

adherencemacrophagesmusculin (MSC)phagocytosispolarizationsecretion

Identifiers

PMID42677049
PMCPMC13527621

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.