Evidence map›Paper›PMID 42676972›Full record

ReviewOphthalmology science2026

The Underutilized Ocular Fundus in Emergency Departments: Current Progress and Future Prospect of Imaging and Artificial Intelligence for Patient Care.

Yujie Wang, Wenyi Hu, Xiayin Zhang, Huan Liao, Siegfried K Wagner, Yueye Wang, Li Li, Ruiye Chen, Xiaomin Zeng, Alex Fan and 27 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

37 authors.

Yujie WangCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Wenyi HuCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Xiayin ZhangSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Huan LiaoFlorey Institute of Neuroscience and Mental Health, University of Melbourne, Melbourne, Victoria, Australia.
Siegfried K WagnerNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Yueye WangSchool of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Li LiCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Ruiye ChenSchool of Psychology, The University of New South Wales Sydney, Kensington, New South Wales, Australia.
Xiaomin ZengGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Alex FanMonash Medical School, Monash University, Melbourne, Victoria, Australia.
Myra B McGuinnessCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Sam FreemanEmergency Department, St Vincent's Hospital (Melbourne) Limited, Fitzroy, Victoria, Australia.
Zihan SunNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Anneke Van Der WaltDepartment of Neurosciences, Central Clinical School, Alfred Centre, Monash University, Melbourne, Victoria, Australia.
Gabriel Dawei YangDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Carmel CrockEmergency Department, The Royal Victorian Eye and Ear Hospital, East Melbourne, Victoria, Australia.
Can Can XueSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Anran RanDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Gary AytonDepartment of Emergency Medicine, Sunshine Hospital, Western Health, St Albans, Victoria, Australia.
Lucia Le-KimDepartment of Emergency Medicine, Sunshine Hospital, Western Health, St Albans, Victoria, Australia.
Honghua YuGuangdong Eye Institute, Department of Ophthalmology, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Tissa WijeratneDepartment of Neurology, Sunshine Hospital, Western Health, St Albans, Victoria, Australia.
Wei WangState Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangdong Provincial Clinical Research Center for Ocular Diseases, Guangzhou, China.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Zongyuan GeAIM for Health Lab, Faculty of Information Technology, Monash University, Melbourne, Victoria, Australia.
David A MackeyCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Carol Y CheungDepartment of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong SAR, China.
Franz E BablEmergency Department, Royal Children's Hospital, Melbourne, Victoria, Australia.
Hamed AkhlaghiEmergency Department, St Vincent's Hospital (Melbourne) Limited, Fitzroy, Victoria, Australia.
Mingguang HeSchool of Optometry, The Hong Kong Polytechnic University, Kowloon, Hong Kong, China.
Peter van WijngaardenCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.
Pearse A KeaneNIHR Biomedical Research Centre, Moorfields Eye Hospital NHS Foundation Trust, London, UK.
Nancy J NewmanDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.
Valérie BiousseDepartment of Ophthalmology, Emory University School of Medicine, Atlanta, Georgia.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore.
Zhuoting ZhuCentre for Eye Research Australia, Royal Victorian Eye and Ear Hospital, Melbourne, Victoria, Australia.

Funding

P30-Core Grant for Vision Research Core CP30EY006360 · NEI · EMORY UNIVERSITY · PI NICKERSON, JOHN M · 1986 to 2025
$15.3M
NEI NIH HHS P30 EY006360
6 · The paper itself

Abstract

Clinical Relevance: The retina is a unique and accessible window to the central nervous system and its vasculature. Ocular fundus examination is crucial for identifying diagnostic red flags indicative of life- and sight-threatening conditions, such as papilledema and central retinal artery occlusion. In the emergency department (ED), prompt recognition of these conditions is essential to reduce the risk of vision loss and serious complications. Methods: This review summarizes advances in ocular fundus examination, imaging, and artificial intelligence (AI) for emergency care. Results: The direct ophthalmoscope, a traditional tool for ocular fundus examination by nonophthalmology providers in the ED, is rarely utilized due to technical limitations and lack of user skill and confidence. Recent advancements in retinal imaging technologies have introduced ocular fundus cameras with OCT as valuable alternatives. The advent of nonmydriatic and portable imaging devices has significantly expanded accessibility, enabling remote image interpretation and facilitating teleophthalmology consultations. Moreover, AI, especially deep-learning technology, has demonstrated considerable potential for automated ocular image interpretation. The latest developments in large language models show promise in providing aids in diagnosis and management. Conclusions: Further research is needed to validate the reliability of AI-powered ocular fundus assessment and to explore how these emerging technologies can be effectively integrated into ED practice to enhance ocular fundus examination and improve patient care.

Indexed as

Artificial intelligenceEmergency departmentOcular fundus examinationOcular fundus imagingRetinal camera

Identifiers

PMID42676972
PMCPMC13527504

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.