ReviewFrontiers in pharmacology2026
Linalool in cancer pharmacology: pharmacokinetic limitations and preclinical cytotoxic evidence for translational development.
Review in Frontiers in pharmacology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
11 authors.
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Abstract
Cancer pharmacology increasingly evaluates plant-derived metabolites as lead compounds, but preclinical cytotoxicity should not be equated with clinical anticancer efficacy. Linalool, an acyclic monoterpene alcohol present in several aromatic plants and essential oils, has been investigated as an isolated compound and as a component of linalool-containing preparations. This critical narrative review evaluates pharmacokinetic evidence related to linalool, delivery considerations, the relevance of extraction methods, and preclinical cancer-model findings, with explicit separation of computational predictions,
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