ArticleFrontiers in surgery2026
Clinical phenotypes of children undergoing adenotonsillectomy: a cluster analysis based on comorbidities and Its association with surgical strategy and length of stay.
Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To identify clinical phenotypes among children undergoing surgery for adenotonsillar hypertrophy using unsupervised cluster analysis based on comorbidities, and to explore the association of phenotypes with obstructive sleep apnea (OSA) severity, surgical procedures, and length of hospital stay (LOS). Methods: This retrospective cohort study included 199 consecutive children who underwent adenoidectomy or adenotonsillectomy between August 2023 and April 2026. Nine binary comorbidity variables were extracted. K-modes clustering was used to partition patients into phenotypic groups. Demographic characteristics, OSA severity, surgical procedures, and LOS were compared. Multivariable negative binomial regression identified independent predictors of LOS. Results: Four phenotypes emerged: allergic-inflammatory ( Conclusions: Comorbidity-based clustering reveals four clinically meaningful phenotypes differing in age, OSA, and otologic surgery needs. LOS is driven by surgical complexity, yet phenotyping aids preoperative planning.
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