Evidence map›Paper›PMID 42676893›Full record

ArticleGenetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference2026

Phase-Alternation and Tree-Initialization to Facilitate Interpretable Rule-based Machine Learning.

Gabriel Lipschutz-Villa, Harsh Bandhey, Khoi Dinh, Michael Heider, Malek Kamoun, Ryan J Urbanowicz

Abstract read
In one paragraph

Article in Genetic and Evolutionary Computation Conference : [proceedings]. Genetic and Evolutionary Computation Conference, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Gabriel Lipschutz-VillaUniversity of Pennsylvania, Philadelphia, PA, USA.
Harsh BandheyCedars Sinai Health Sciences University, Los Angeles, CA, USA.
Khoi DinhUniversity of Pennsylvania, Philadelphia, PA, USA.
Michael HeiderUniversität Augsburg, Augsburg, Germany.
Malek KamounUniversity of Pennsylvania, Philadelphia, PA, USA.
Ryan J UrbanowiczCedars Sinai Health Sciences, University, Los Angeles, CA, USA.

Funding

Technology Identification and Training CoreP30AG073105 · NIA · UNIVERSITY OF PENNSYLVANIA · PI DEMIRIS, GEORGE, KARLAWISH, JASON H · 2021 to 2025
$21.2M
MicroRNAs as Biomarkers for Obstructive Sleep ApneaP01HL160471 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI Anne Justice · 2023 to 2026
$11.9M
Artificial Intelligence Strategies for Alzheimer's Disease ResearchU01AG066833 · NIA · CEDARS-SINAI MEDICAL CENTER · PI MOORE, JASON H., RITCHIE, MARYLYN D · 2022 to 2025
$6.7M
HLA Immunogenetics and kidney allograft outcomesR01AI173095 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI Malek Kamoun · 2023 to 2026
$3.1M
NHLBI NIH HHS P01 HL160471NIAID NIH HHS R01 AI173095NIA NIH HHS P30 AG073105NIA NIH HHS U01 AG066833
6 · The paper itself

Abstract

Interpretable machine learning is important for scientific, biomedical, and other high-stakes domains where transparency, trust, and human understanding of models are required. Recently, an evolutionary rule-based machine learning algorithm called HEROS was proposed, which separated rule from rule-set discovery each with distinct multi-objective optimization strategies yielding a two-phase, noise agnostic framework that found accurate, highly compact, and interpretable solutions on a diverse set of challenging benchmarks without requiring hyperparameter optimizations. However, HEROS is currently limited by its strictly sequential two-phase design which requires committing in advance to a fixed number of rule-discovery iterations. This work extends HEROS with a phase alternation scheme interleaving rule discovery and rule-set optimization. This enables refinement of both tasks throughout training in an 'anytime-algorithm' manner. We also introduce a tree-based rule initialization strategy to accelerate early-stage rule discovery. These extensions aim to preserve the empirical performance of the original HEROS framework under a similar computational budget while providing greater flexibility for algorithm application and problem scalability. Using the same diverse set of benchmark datasets, we evaluate and compare these HEROS extensions to the original HEROS algorithm and established rule-based learning systems including RIPPER and BioHEL. We demonstrate the advantages of this extended HEROS framework.

Indexed as

InterpretabilityLearning Classifier SystemsMulti-objective OptimizationRule-based Machine LearningSupervised Learning

Identifiers

PMID42676893
PMCPMC13528405

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.