ArticleFrontiers in nutrition2026
Dual effects of fasting on gut microbiota and metabolism: protective adaptation versus barrier dysfunction risks.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Fasting reshapes gut microbiota and metabolism, but its time-dependent dual impacts on intestinal barrier remain unclear. This study explored how 12 h and 24 h acute fasting modulate gut microbes, metabolites, epithelial structure and inflammatory resilience in mice. Methods: C57BL/6 J mice were assigned to ad libitum feeding, 12 h fasting and 24 h fasting groups. We integrated PacBio 16S rRNA sequencing, untargeted LC-MS metabolomics, colon/cecum histology, Occludin immunofluorescence and CLP sepsis model, with LEfSe, multivariate statistics and correlation analysis for data interpretation. Data are available via MetaboLights with identifier MTBLS15098. Results: Fasting induced time-dependent microbial and metabolic remodeling: Discussion: Short-term fasting generates favorable microbial-metabolic adaptation yet initiates mild epithelial injury, while 24 h fasting aggravates barrier defects and weakens anti-inflammatory resilience. Beneficial microbiota signatures are decoupled from intact mucosa, indicating fasting duration determines the balance between gut adaptation and epithelial vulnerability.
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