Evidence map›Paper›PMID 42676837›Full record

ArticleJournal of oral microbiology2026

Severity-dependent alterations in oral microbiota and antibiotic resistance in children with dental fluorosis.

Yuting Xia, Shifu Peng, Jiannan Yu, Yang Wang, Yunjie Ye, Mao Liu, Li Shang, Xing Cui, Peihua Wang, Zhen Ding

Abstract read
In one paragraph

Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Yuting XiaDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.ORCID https://orcid.org/0000-0001-5684-3195
Shifu PengDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Jiannan YuDepartment of Pediatric Dental Prevention, The Affiliated Stomatological Hospital of Nanjing Medical University, Nanjing, China.
Yang WangDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Yunjie YeDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Mao LiuDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Li ShangDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Xing CuiNanjing Stomatological Hospital, Affiliated Hospital of Medical School, Institute of Stomatology, Nanjing University, Nanjing, China.
Peihua WangDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.
Zhen DingDepartment for Environmental Health (Endemic Disease Control and Prevention), Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Backgroud: Dental fluorosis is a prevalent endemic condition, yet its impact on the oral microbiota structure and resistance in children remains understudied. Objective: To assess the microbial composition, diversity, functional pathways and co-occurrence patterns among urinary fluoride (UF), bacterial taxa and antibiotic resistance genes in relation to fluorosis severity. Design: Metagenomic analysis of dental plaque was conducted on 96 school-aged children, who were grouped into normal, dubious, very mild, mild, moderate and severe base on fluorosis severity. Results: Microbial diversity increased with fluorosis severity. Conclusions: These findings highlight severity-dependent shifts in the oral microbiota and resistance, warranting further investigation into fluoride's public health implications.

Indexed as

antibiotic resistancechildrenDental fluorosisdental plaquemetagenomic analysisoral microbiota

Identifiers

PMID42676837
PMCPMC13528121

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.