ArticleFrontiers in medicine2026
Painful penile mass as an initial manifestation of systemic diffuse large B-cell lymphoma: a case report.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Diffuse large B-cell lymphoma (DLBCL) involving the penis is an exceptionally rare extranodal malignancy and is frequently misdiagnosed as penile carcinoma or infectious conditions because of its nonspecific clinical presentation. Case presentation: A 58-year-old man presented with a progressively enlarging painful penile mass for 3 months that was refractory to empirical antibiotic therapy. Ultrasound-guided core biopsy of the penile shaft mass revealed diffuse large B-cell lymphoma, centroblastic type, non-germinal center B-cell subtype with MYC and BCL-2 double expression. Fluorodeoxyglucose positron emission tomography/computed tomography (FDG PET/CT) demonstrated intense uptake in the penis with additional gastric involvement confirmed by biopsy, consistent with Lugano stage IV disease. The patient received curative-intent systemic chemo-immunotherapy with Rituximab plus Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone (R-CHOP) and subsequently achieved complete metabolic remission on follow-up FDG PET/CT. Conclusion: This case highlights an unusual presentation of systemic DLBCL as a painful penile mass and underscores the pivotal role of FDG PET/CT in detecting occult extranodal involvement, accurately staging disease, and guiding appropriate management.
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