ArticleBiological psychiatry global open science2026
Neurocognitive Mechanisms of Preventive Cognitive Therapy as Relapse Prevention in Remitted Major Depressive Disorder: A Randomized Controlled Trial.
Article in Biological psychiatry global open science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Major depressive disorder (MDD) is a highly recurrent psychiatric disorder. Understanding mechanisms of effective treatments that lower recurrence risk provides an opportunity to identify neurocognitive targets for recurrence prevention. Here we studied neurocognitive mechanisms of preventive cognitive therapy (PCT). Methods: Fifty medication-free individuals who were remitted from MDD and at high risk for recurrence were randomized to 8 sessions of protocolized PCT or a waiting list control (WLC) group as part of the NEWPRIDE (Neurocognitive Working Mechanisms of the Prevention of Relapse in Depression) study (NTR5368). Individuals were assessed at baseline and a 3-month follow-up using functional magnetic resonance imaging, cognitive testing, and clinical questionnaires. Primary outcomes were changes in 1) prefrontal cortex activation during effortful emotion regulation and 2) biased automatic processing, covering positive and negative affective dimensions. Secondary outcomes included changes in symptomatology, cognitive and affective reactivity, and emotion regulation styles. Linear mixed models and repeated-measures analyses of variance were conducted to test for PCT-induced changes. Results: Following PCT (vs. WLC), decreased (dorso)medial prefrontal activation during effortful regulation of positive affect and decreased pregenual anterior cingulate activation during effortful regulation of positive and negative affect were observed, alongside increased reactivity of positive self-related thinking and lower negative affect responsivity. Conclusions: Results from this primary analysis show that PCT, which is a nonpharmacological preventive intervention, has neuromodulatory effects on the prefrontal brain circuitry that underpin the regulation of affect and boost positive thinking about oneself, which is associated with lower negative affect. Training the affect and beliefs to more positive content may strengthen the neural circuitry that is implicated in guarding against the activation of negative affect and beliefs in the face of daily negative events, thereby lowering the risk for recurrence.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.