Evidence map›Paper›PMID 42676672›Full record

ArticleFrontiers in immunology2026

Identification of the immunoprotective activity of Mori Cortex Radicis ethanol extract against aquaculture pathogens (

Xing Zhang, Ling Zhu, Yixin Yu, Kai Wang, Qinkai Hu, Xuan Huang, Guangbao Zhu, Jingjing Ma, Shanshan Li, Xiang Liu

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Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Xing Zhang *Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Fuyang Normal University, Fuyang, China.
Ling Zhu *Anhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Fuyang Normal University, Fuyang, China.
Yixin YuAnhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Fuyang Normal University, Fuyang, China.
Kai WangAnhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Fuyang Normal University, Fuyang, China.
Qinkai HuRural Revitalization Collaborative Technology Service Center of Anhui Province, Fuyang Normal University, Fuyang, China.
Xuan HuangRural Revitalization Collaborative Technology Service Center of Anhui Province, Fuyang Normal University, Fuyang, China.
Guangbao ZhuRural Revitalization Collaborative Technology Service Center of Anhui Province, Fuyang Normal University, Fuyang, China.
Jingjing MaRural Revitalization Collaborative Technology Service Center of Anhui Province, Fuyang Normal University, Fuyang, China.
Shanshan LiRural Revitalization Collaborative Technology Service Center of Anhui Province, Fuyang Normal University, Fuyang, China.
Xiang LiuAnhui Province Key Laboratory of Embryo Development and Reproductive Regulation, Fuyang Normal University, Fuyang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: Mori Cortex Radicis (MCR) is an important Chinese herbal medicine with antitussive, anti-inflammatory, and analgesic effects. It is abundant in resources and low in cost, but its application in the control of fish pathogens has been insufficiently studied. Methods: We employed an ethanol extraction method to obtain the MCR ethanol extract (MCR-EE), and analyzed its small-molecule and macromolecular components using LC-MS and commercial kits, respectively. Subsequently, using a crucian carp ( Results: The MCR-EE was prepared. The contents of proteins, polysaccharides, and polyphenols of MCR-EE were 0.7%, 0.44%, and 1.21%, respectively. A total of 646 small substances were identified in MCR-EE, and the five most abundant small-molecule compounds were L(+)-Arginine, 1-Deoxynojirimycin, 9,12,13-Todea, 4-Guanidinobutanoic acid, and Kelampayoside A. The MCR-EE enhanced the general phagocytic activity of fish blood leukocytes and the activity of immune factors. The immune protection rates of MCR-EE against Conclusion: MCR-EE exhibits immunomodulatory activity and holds promise as an immunostimulant for the prevention and control of fish pathogens (

Indexed as

Aeromonas veroniiDrugs, Chinese HerbalFish DiseasesGram-Negative Bacterial InfectionsPlant ExtractsPseudomonas aeruginosaPseudomonas InfectionsAnimalsAquacultureCarpsEthanolDrugs, Chinese HerbalEthanolPlant ExtractsAeromonas veroniiethanol extractimmune protectionLC-MSMori Cortex RadicisPseudomonas aeruginosa

Identifiers

PMID42676672
PMCPMC13526930

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.