Trial reportFrontiers in medicine2026
Effect of vaginal delivery history on oliceridine ED₅₀ combined with propofol during painless hysteroscopy: a modified Dixon sequential study.
Trial report in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: To determine the median effective dose (ED Methods: Patients scheduled for hysteroscopy who met the inclusion criteria were stratified into two cohorts: those with no history of vaginal delivery (NVD cohort, including nulliparous women and those with prior cesarean section only) and those with a history of vaginal delivery (VD cohort). Based on the Dixon sequential outcomes, patients were further classified as negative subcohort (successful hysteroscopy, indicating no body movement) or positive subcohort (failed hysteroscopy, indicating body movement). An initial intravenous oliceridine dose of 20 μg/kg was administered, followed by propofol 1.5 mg/kg after 2 min. Successful induction was defined as a Modified Observer's Assessment of Alertness/Sedation (MOAA/S) score of 0 (no response to trapezius squeeze) and a bispectral index (BIS) < 60. Intraoperative propofol boluses (0.5 mg/kg) maintained BIS between 40 and 60. Oliceridine dosing was adjusted using a modified Dixon up-and-down sequential method (dose ratio 1:1.2 between adjacent levels) until at least seven crossover points were recorded. The primary outcome was the ED Results: The ED Conclusion: During painless hysteroscopy, the ED Clinical trial registration: ChiCTR2500095126 (https://www.chictr.org.cn).
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