Evidence map›Paper›PMID 42676646›Full record

ArticleFrontiers in surgery2026

Association between postoperative silver sulfadiazine dressings and surgical site infection after skin cancer excision: an observational cohort study with historical controls.

Barbara De Angelis, Davide Johan Bottini, Chiara Di Segni, Lorenzo Secondi, Marco Gerardi, Margarida Fernandes Lopes Morais D'Autilio, Nico Preite, Alfredo Pisapia, Pietro Gentile, Dario Crocoli and 5 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Barbara De AngelisDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Davide Johan BottiniDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Chiara Di SegniPoliclinico Casilino, Rome, Italy.
Lorenzo SecondiDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Marco GerardiDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Margarida Fernandes Lopes Morais D'AutilioDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Nico PreiteDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Alfredo PisapiaDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Pietro GentileDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Dario CrocoliPlastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Daniele Di GiovanniDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Mariachiara CarestiaDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Leonardo PalombiDepartment of Biomedicine and Prevention, University of Rome Tor Vergata, Rome, Italy.
Fabrizio OrlandiDepartment of Plastic and Reconstructive Surgery, University of Rome Tor Vergata, Rome, Italy.
Valerio CervelliUniversity "Our Lady of Good Counsel", Tirana, Albania.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Surgical site infections (SSIs) remain a relevant postoperative complication in dermatologic surgery, negatively affecting wound healing, patient outcomes, and healthcare costs. Although the baseline infection risk after clean skin cancer surgery is relatively low, preventive strategies remain clinically important. Silver sulfadiazine (SSD) is a topical antimicrobial agent with broad-spectrum antibacterial activity; however, its preventive role in clean oncologic dermatologic surgery remains insufficiently investigated. This study evaluated the association between postoperative SSD-based dressings and SSI occurrence after skin cancer excision. Methods: A non-randomized observational cohort study with a non-concurrent historical control group was conducted including 800 patients undergoing excision of basal cell carcinoma or squamous cell carcinoma. The intervention group ( Results: At T1, SSIs occurred in 36/400 patients (9.0%) in the SSD group compared with 72/400 patients (18.0%) in the control group (RR = 0.50; 95% CI: 0.34-0.73; Conclusion: Postoperative SSD-based dressings were associated with a lower incidence of early SSI after skin cancer excision. Because of the non-randomized design and the use of non-concurrent historical controls, the observed reduction should be interpreted as an association rather than proof of causality. Further prospective randomized studies are warranted.

Indexed as

basal cell carcinoma (basalioma)dermatologic surgeryobservational cohort studysilver sulfadiazineskin cancersquamous cell carcinomasurgical site infection (SSI)wound care

Identifiers

PMID42676646
PMCPMC13526970

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.