Temporal progression of bone loss, trabecular microarchitectural deterioration, and mechanical impairment in a rat model of collagen-induced arthritis.

Xuan Cheng, Yun Ling, Jun Xie, Lianbo Xiao, Xiong Shi, Chenxin Gao

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Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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6 authors.

Xuan ChengDepartment of Joint Orthopedics, Guanghua Hospital Affiliated to Shanghai, University of Traditional Chinese Medicine, Shanghai, China.

Yun LingDepartment of Joint Orthopedics, Guanghua Hospital Affiliated to Shanghai, University of Traditional Chinese Medicine, Shanghai, China.

Jun XieDepartment of Joint Orthopedics, Guanghua Hospital Affiliated to Shanghai, University of Traditional Chinese Medicine, Shanghai, China.

Lianbo XiaoDepartment of Joint Orthopedics, Guanghua Hospital Affiliated to Shanghai, University of Traditional Chinese Medicine, Shanghai, China.

Xiong ShiDepartment of Joint Orthopedics, Guanghua Hospital Affiliated to Shanghai, University of Traditional Chinese Medicine, Shanghai, China.

Chenxin GaoDepartment of Joint Orthopedics, Guanghua Hospital Affiliated to Shanghai, University of Traditional Chinese Medicine, Shanghai, China.

Funding

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6 · The paper itself

Abstract

Aim: This study aimed to characterize the temporal progression of bone loss, trabecular microarchitectural deterioration, and mechanical impairment in a rat model of collagen-induced arthritis (CIA). Methods: CIA was induced in Wistar rats via subcutaneous injection of bovine type II collagen. Following CIA induction, rats with a clinical arthritis score of ≥2 were considered to have successfully developed arthritis and were allocated to six experimental groups ( Results: Micro-CT analysis revealed a significant decrease in bone mineral density (BMD) and trabecular thickness (Tb.Th) as early as 2 weeks post-induction ( Conclusion: CIA induced early deterioration of bone mass and trabecular microarchitecture, characterized by significant reductions in BMD and Tb.Th. No statistically significant between-group differences in Tb.N or Tb.Sp were identified at individual time points after multiplicity correction. Mechanical impairment of both femoral and vertebral bone was also observed during disease progression. These findings indicate that microarchitectural deterioration and loss of bone strength may follow partly distinct temporal patterns in CIA rats and underscore the importance of early assessment of skeletal changes in inflammatory arthritis.

Indexed as

bone losscollagen-induced arthritisinflammationosteoporosisrheumatoid arthritis

Identifiers

PMID42676639

DOI10.3389/fmed.2026.1885782

PMCPMC13527451

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