Evidence map›Paper›PMID 42676559›Full record

ArticleHealth science reports2026

Mediterranean Diet and Micronutrient Adequacy in Relation to Relapsing-Remitting Multiple Sclerosis Risk: A Case-Control Study.

Maryam Ahmadi-Khorram, Alireza Hatami, Mostafa Shahraki Jazinaki, Yasaman Aali, Maedeh Nojoumi, Fatemeh Keykhaei, Ali Jafarzadeh Esfehani, Mohsen Nematy

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Article in Health science reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maryam Ahmadi-KhorramDepartment of Clinical Nutrition, School of Nutritional Sciences and Dietetics Tehran University of Medical Sciences Tehran Iran.ORCID https://orcid.org/0009-0008-0850-6934
Alireza HatamiDepartment of Clinical Nutrition, School of Nutrition and Food Science, Food Security Research Center Isfahan University of Medical Sciences Isfahan Iran.ORCID https://orcid.org/0009-0001-8712-0165
Mostafa Shahraki JazinakiDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0009-0006-6526-8712
Yasaman AaliDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0000-0001-8320-6300
Maedeh NojoumiDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0009-0000-7494-7895
Fatemeh KeykhaeiDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.
Ali Jafarzadeh EsfehaniDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0000-0002-4185-2694
Mohsen NematyDepartment of Nutrition, Faculty of Medicine Mashhad University of Medical Sciences Mashhad Iran.ORCID https://orcid.org/0000-0003-3202-2709

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Multiple sclerosis (MS) is a chronic autoimmune and neurodegenerative disease influenced by environmental factors, including diet. The Mediterranean Diet (MeDi), rich in anti-inflammatory and antioxidant compounds, and micronutrient adequacy may reduce MS risk and progression. Aim: This study aims to examine the associations between the Mediterranean Diet Score (MDS), Mean Adequacy Ratio (MAR), and MS risk in a case-control setting. Methods: This case-control study included 197 newly diagnosed relapsing-remitting MS patients (aged 18-65 years) from Iran, and 200 matched controls without neurological diseases. Dietary intake was assessed using a validated semi-quantitative food frequency questionnaire. MDS was calculated based on nine dietary components, and MAR was computed as the average Nutrient Adequacy Ratio for seven micronutrients. Adjusted binary logistic regression estimated odds ratios (ORs) for MS risk across MDS and MAR tertiles. Results: Higher MDS and MAR were associated with significantly reduced MS risk. Individuals in the highest MDS tertile had 47% lower odds of MS (OR: 0.53, 95% CI: 0.29-0.98, Conclusion: Higher adherence to the Mediterranean Diet and better micronutrient adequacy are associated with a reduced risk of MS. These findings highlight the potential of dietary interventions as a cost-effective strategy for MS prevention, warranting further longitudinal and interventional studies to establish causality and inform public health strategies.

Indexed as

food frequency questionnaireMediterranean dietmicronutrient adequacymultiple sclerosisnutritional epidemiology

Identifiers

PMID42676559
PMCPMC13527407

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.