ArticleJournal of inflammation research2026
The Inflammatory Cytokine Profile in Acute Myocardial Infarction and Its Impact on in-Hospital Mortality.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Purpose: Inflammation is a common pathway in acute or chronic cardiac injury. This study aimed to explore the characteristics of systemic inflammatory responses in acute myocardial infarction (AMI) and find the key inflammatory factors in the prognosis of AMI patients. Patients and Methods: A total of 146 patients with AMI and 468 patients with valvular heart disease (VHD) from West China Hospital of Sichuan University between January 2022 to September 2024 were included in this retrospective study using electronic medical records. Plasma cytokines (including IL-1β, IL-2, IL-4, IL-5, IL-6, IL-8, IL-10, IL-12p70, IL-17, interferon-α, interferon-γ, and tumor necrosis factor-α) were detected by flow cytometry within 24 hours of admission. Multivariate logistic regression analysis and survival analysis were conducted to identify factors independently associated with in-hospital mortality in AMI patients. Results: AMI patients exhibited an acute "high inflammatory status", characterized by markedly elevated Interleukin (IL)-6 and IL-10, compared with the low-grade inflammation in VHD (all P<0.001). The multivariate logistic regression model showed that except for the traditional risk factors (age, systolic blood pressure, and heart rate), IL-1β (odds ratio (OR)=1.093, 95% confidence intervals(CI): 1.019-1.172) remained an independent predictor of in-hospital mortality in AMI patients. The IL-1β-based model provided discrimination similar to the Global Registry of Acute Coronary Events Score (AUC 0.819 vs 0.812), and both scores demonstrated significant dose-response associations with mortality risk (IL-1β-based risk score: Hazard Ratio(HR) = 2.67 per SD, 95% CI: 1.82-3.90; GRACE score: HR = 2.66 per SD, 95% CI: 1.75-4.05). Conclusion: This study revealed that AMI triggered a high-grade systemic inflammatory status contrasted to that in VHD. Crucially, the upstream inflammatory mediator IL-1β was identified as an independent risk factor for in-hospital mortality in AMI patients. Whatever in the prognosis performance or risk assessment IL-1β-based risk score had the similar effects to GRACE score.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.