ArticleFrontiers in medicine2026
The prognostic value of liver function abnormalities in adult secondary hemophagocytic lymphohistiocytosis.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Adult secondary hemophagocytic lymphohistiocytosis (sHLH) is a disorder of immune dysregulation and hyperinflammation that is frequently accompanied by hepatic dysfunction. Evidence describing liver function test (LFT) abnormalities and their prognostic associations in adults with sHLH remains limited. Methods: In this retrospective study, clinical data and LFT results were obtained at admission from 269 patients with sHLH. Multivariable logistic regression and restricted cubic spline models were used to evaluate the associations between LFTs and in-hospital mortality. Results: Abnormal alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP), and total bilirubin (TBIL) levels were present in 56.5, 75.8, 61.3, and 42.0% of patients, respectively. In multivariable models, higher log-transformed ALP was associated with 28-day mortality (OR 2.84, 95% CI 1.16-7.22; Conclusion: Abnormal LFTs were common at admission, and ALP and TBIL may be useful prognostic markers of short-term in-hospital mortality in adults with sHLH.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.