ArticleFrontiers in parasitology2026
Navigating imaging artifacts: challenges with visualizing intrinsically fluorescent antimalarials.
Article in Frontiers in parasitology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Elucidating the target of an antiparasitic small molecule can aid in the drug development process. However, various technical challenges related to parasite biology prevent timely target identification. Microscopy methods determining the co-localization of a drug with subcellular markers is a powerful approach that provides evidence of its localization within the cell. This technique can help pinpoint the primary site of action of novel therapeutics, which can assist in elucidating their mode of action. Intrinsically fluorescent drugs allow for subcellular localization without extensive medicinal chemistry. We imaged the intrinsically fluorescent drugs PRC1590 and quinine with digestive vacuole stains to determine these compounds' localization in the malaria parasite,
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