ArticleFrontiers in medicine2026
Changes in multimodal MRI parameters following orbital decompression surgery for thyroid-associated ophthalmopathy and their associations with clinical outcomes.
Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Objective: To evaluate postoperative changes in multimodal quantitative magnetic resonance imaging (MRI) parameters after orbital decompression in thyroid-associated ophthalmopathy and explore their associations with clinical outcomes. Methods: This retrospective study included 47 patients (61 eyes) assessed before and 6 months after surgery. Eye-level longitudinal outcomes were analyzed using linear mixed-effects models with random intercepts for patients and eyes nested within patients. Graves' Ophthalmopathy Quality of Life questionnaire (GO-QOL) outcomes were analyzed using patient-level mixed-effects models. MRI-clinical associations were assessed using generalized estimating equations or multivariable linear regression. Benjamini-Hochberg false discovery rate correction was applied within prespecified hypothesis families. Results: After correction, proptosis and best-corrected visual acuity improved significantly, as did visual-function, appearance, and total GO-QOL scores. Multiple structural and diffusion-related MRI parameters also changed significantly after surgery. Greater reductions in corneal protrusion distance were associated with greater reductions in proptosis ( Conclusion: Multimodal quantitative MRI detected postoperative structural and diffusion-related changes after orbital decompression. Reductions in the vertical orbital apex area index and fat space apparent diffusion coefficient showed exploratory associations with patient-reported visual-function improvement, although robustness varied across sensitivity analyses. These measures may complement, but not replace, clinical assessment.
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