ArticleJournal of clinical practice and research2026
Multi-Omics Integration Identifies Ferroptosis-Related miRNA-mRNA Networks and Independent Prognostic miRNAs in Triple-Negative Breast Cancer.
Article in Journal of clinical practice and research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Objective: This study aimed to comprehensively characterize the transcriptomic and proteomic landscape of ferroptosis-associated mRNAs, miRNAs, and proteins, elucidate subtype-specific regulatory networks, and identify potential prognostic biomarkers in triple-negative breast cancer (TNBC). Materials and Methods: Using the TCGA-BRCA cohort for discovery and the METABRIC dataset for validation, we performed differential expression and functional enrichment analyses comparing TNBC and non-TNBC subtypes. An integrated miRNA-mRNA regulatory network was constructed, and multivariable Cox proportional hazards regression analysis was performed to evaluate the prognostic value of the identified biomarkers. Results: TNBC exhibited profound transcriptional dysregulation, characterized by the marked upregulation of the iron-sequestering gene FTMT (log Conclusion: This multi-omics integration maps the ferroptosis-related regulatory landscape of TNBC. Although specific mRNAs serve as key structural hubs, hsa-miR-378c and hsa-miR-449a emerge as robust independent prognostic biomarkers, providing important insights into TNBC risk stratification and potential targeted therapeutic strategies.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.