ArticleFrontiers in immunology2026
Short-term mycophenolic acid withdrawal is associated with temporal changes in immune cell composition in mRNA-1273-vaccinated kidney transplant recipients: insights from high-dimensional immune profiling.
Article in Frontiers in immunology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Short-term mycophenolic acid (MPA) withdrawal is common in kidney transplant recipients with severe infections and was extended during the COVID-19 pandemic to improve vaccine immunogenicity, yet its effects on immune cell dynamics remain mechanistically understudied. Methods: We performed high-dimensional flow cytometry combined with unsupervised computational clustering to analyze longitudinal peripheral blood mononuclear cell samples from kidney transplant recipients who received mRNA-1273 vaccination. Samples were collected before and after a 5-week temporary MPA discontinuation, and the results were compared with those of vaccinated patients maintained on standard triple immunosuppression. Results: Compared with continued triple immunosuppression (N = 13), MPA withdrawal (N = 11) was associated with temporal shifts in major immune compartments, including increases in the frequencies of CD4 Conclusions: Short-term MPA withdrawal was associated with selective temporal immune shifts, including increased relative frequencies of CD4
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