Evidence map›Paper›PMID 42676351›Full record

ArticleFrontiers in cellular and infection microbiology2026

Trypanothione reductase overexpression increases the infectivity of

Myslene Soares Fonseca, Rodrigo Prado Rodrigues Miranda, Job Domingos Filho Inácio, Tania Zaverucha Do Valle, Elmo Eduardo Almeida-Amaral

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Myslene Soares FonsecaLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Rodrigo Prado Rodrigues MirandaLaboratório de Epidemiologia e Malformações Congênitas, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Job Domingos Filho InácioLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Tania Zaverucha Do ValleLaboratório de Protozoologia, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.
Elmo Eduardo Almeida-AmaralLaboratório de Bioquímica de Tripanosomatídeos, Instituto Oswaldo Cruz, Fundação Oswaldo Cruz, Rio de Janeiro, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Leishmaniasis is a neglected tropical disease that imposes a significant global health burden. To establish persistent infections, parasites must overcome oxidative stress generated by host immune responses, a process for which the parasite-specific enzyme trypanothione reductase (TR) is critical. While TR has been implicated in infectivity, its precise role in governing infectivity remains incompletely understood. This study aimed to investigate the hypothesis that TR activity is a key determinant of parasite infectivity. We first compared TR activity between pathogenic

Indexed as

HomeostasisLeishmaniaNADH, NADPH OxidoreductasesOxidative StressAmino Acid SubstitutionAnimalsDisease Models, AnimalFemaleHydrogen PeroxideLeishmania infantumLeishmaniasisMacrophagesMacrophages, PeritonealMiceMice, Inbred BALB COxidation-ReductionHydrogen PeroxideNADH, NADPH Oxidoreductasestrypanothione reductaseantioxidant defensehost‒parasite interactioninfectivityLeishmaniaoxidative stresstrypanothione reductase

Identifiers

PMID42676351
PMCPMC13526550

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.