Evidence map›Paper›PMID 42676345›Full record

ArticleFrontiers in oncology2026

Chromosome 1q alterations in transplant-eligible multiple myeloma: clinical impact of copy number and co-occurring high-risk cytogenetic features.

Irene Strassl, Daniel Bindeus, Jonathan Burghofer, Martin Erdel, Veronika Buxhofer-Ausch, Sigrid Machherndl-Spandl, Olga Saini, Dagmar Wipplinger, Emine Kaynak, Robert Milanov and 7 more

Abstract read
In one paragraph

Article in Frontiers in oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

17 authors.

Irene StrasslDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Daniel BindeusDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Jonathan BurghoferLaboratory for Molecular Genetics Diagnostics, Ordensklinikum Linz, Linz, Austria.
Martin ErdelLaboratory for Molecular Genetics Diagnostics, Ordensklinikum Linz, Linz, Austria.
Veronika Buxhofer-AuschDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Sigrid Machherndl-SpandlDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Olga SainiDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Dagmar WipplingerDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Emine KaynakDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Robert MilanovDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Natalia RotterDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Petra HasengruberDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Lorenz MairDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Alexander NikoloudisDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Ansgar WeltermannDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Holger RumpoldDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.
Johannes ClausenDepartment of Internal Medicine I: Hematology with Stem Cell Transplantation, Hemostaseology and Medical Oncology, Ordensklinikum Linz, Linz, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Chromosome 1q abnormalities are among the most frequent cytogenetic alterations in multiple myeloma (MM), yet their prognostic relevance has been reported inconsistently and varies across current risk stratification models. Methods: We conducted a retrospective single-center study to evaluate the clinical impact of 1q abnormalities in 140 patients with newly diagnosed MM undergoing autologous stem cell transplantation (ASCT). Results: Fluorescence Conclusion: In conclusion, the prognostic relevance of chromosome 1q alterations in transplant-eligible newly diagnosed MM appears to be primarily driven by copy number burden and co-occurrence with other high-risk lesions rather than by their isolated presence. These findings support the integration of 1q abnormalities into composite risk models to improve risk stratification.

Indexed as

1q alterations1q amplification1q gaincytogeneticsmultiple myeloma

Identifiers

PMID42676345
PMCPMC13526574

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.