Evidence map›Paper›PMID 42676036›Full record

ArticleBiomolecules & therapeutics2026

Transcriptional Reprogramming of GPCR Signaling Pathways in the Frontal Cortex of Morphine Dependent Mice.

Mijin Kim, Sohyeon Moon, Taddesse Yayeh, Thea Villa, Seikwan Oh

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Mijin KimDepartment of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
Sohyeon MoonDepartment of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
Taddesse YayehDepartment of Veterinary Science, College of Agriculture and Environmental Sciences, Bahir Dar University, Bahir Dar, Ethiopia.
Thea VillaDepartment of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.
Seikwan OhDepartment of Molecular Medicine, School of Medicine, Ewha Womans University, Seoul 07804, Republic of Korea.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Repeated morphine administration for managing persistent pain frequently induces both physical and psychological dependence, accompanied by alterations in cortical gene expression. To elucidate the molecular underpinnings of morphine dependence, gene expression in the frontal cortex of mice subjected to acute and chronic morphine treatment was profiled using microarray analysis and validated by semi-quantitative PCR. Genes including

Indexed as

CREBDopamine receptorGene expressionsGPCR signalingMicroarrayMorphine

Identifiers

PMID42676036
PMCPMC13534903

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.