Evidence map›Paper›PMID 42676035›Full record

ArticleBiomolecules & therapeutics2026

Role of ATOH8 in Mitigating Cardiac Fibrosis in Heart Failure via Inhibition of the Transcriptional Repression of Smad7 by RUNX2.

Chong Chen, Yapan Yang, Chengyingjie Yang, Chuanyu Gao, Yuhao Liu, Honghui Yang, Xiaohu Wang, Yachen Zhang, Zhuowang Ge

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Biomolecules & therapeutics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Chong ChenDepartment of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Yapan YangDepartment of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Chengyingjie YangDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Chuanyu GaoHenan Key Laboratory of Coronary Heart Disease Control & Prevention, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Yuhao LiuDepartment of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Honghui YangDepartment of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Xiaohu WangDepartment of Cardiology, Central China Fuwai Hospital of Zhengzhou University, Zhengzhou, Henan 450003, China.
Yachen ZhangDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.
Zhuowang GeDepartment of Cardiology, Xinhua Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai 200092, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cardiac fibrosis is a major driver of heart failure and a key therapeutic target. Here, we demonstrated the role of atonal homologue 8 (ATOH8) in the modulation of cardiac fibrosis in heart failure. The expression of ATOH8 was significantly reduced in patients with heart failure and in the left ventricular tissues of model mice. ATOH8 silencing resulted in the worsening of fibrosis, and adenovirus- induced overexpression of ATOH8 attenuated the progression of cardiac fibrosis under

Indexed as

ATOH8Cardiac fibrosisHeart failureRUNX2Smad7

Identifiers

PMID42676035
PMCPMC13534946

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.