Evidence map›Paper›PMID 42675878›Full record

ArticleCanadian journal of gastroenterology & hepatology2026

Predictors of Mortality After Liver Transplantation for Acute Liver Failure: A Multicenter Cohort Study.

Micheli Fortunato Domingos, Júlio Cezar Uili Coelho, Eduardo José Brommelstroet Ramos, Jorge Eduardo Fouto Matias, Fabio Silveira, João Eduardo Leal Nicoluzzi, Nertan Luiz Tefilli, Julio Cesar Wiederkehr, Abdo Imad El Tawil, Gabriel Kindermann de Farias

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Canadian journal of gastroenterology & hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Micheli Fortunato DomingosDepartment of Surgery and Transplantation, Nossa Senhora das Graças Hospital, Curitiba, State of Paraná, Brazil.ORCID https://orcid.org/0000-0001-5577-2209
Júlio Cezar Uili CoelhoDepartment of Surgery and Transplantation, Nossa Senhora das Graças Hospital, Curitiba, State of Paraná, Brazil.ORCID https://orcid.org/0000-0002-7622-8592
Eduardo José Brommelstroet RamosDepartment of Surgery and Transplantation, Nossa Senhora das Graças Hospital, Curitiba, State of Paraná, Brazil.ORCID https://orcid.org/0000-0002-7151-9956
Jorge Eduardo Fouto MatiasDepartment of Surgery and Transplantation, Nossa Senhora das Graças Hospital, Curitiba, State of Paraná, Brazil.ORCID https://orcid.org/0000-0001-6377-8870
Fabio SilveiraDepartment of Transplantation, Rocio Hospital, Campo Largo, State of Paraná, Brazil.ORCID https://orcid.org/0000-0002-0080-3861
João Eduardo Leal NicoluzziDepartment of Transplantation, Angelina Caron Hospital, Campina Grande do Sul, State of Paraná, Brazil.ORCID https://orcid.org/0000-0002-0903-5993
Nertan Luiz TefilliDepartment of Transplantation, São Vicente Hospital, Curitiba, State of Paraná, Brazil.ORCID https://orcid.org/0000-0002-2822-7579
Julio Cesar WiederkehrDepartment of Surgery and Transplantation, Clinical Hospital, Federal University of Paraná, Curitiba, State of Paraná, Brazil, ufpr.br.ORCID https://orcid.org/0000-0002-5658-2404
Abdo Imad El TawilDepartment of Transplantation, Mackenzie Evangelical University Hospital, Curitiba, State of Paraná, Brazil.ORCID https://orcid.org/0009-0000-6218-7446
Gabriel Kindermann de FariasDepartment of Transplantation, Santa Isabel Hospital, Blumenau, State of Santa Catarina, Brazil, hsi.org.br.ORCID https://orcid.org/0000-0002-8744-3191

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionAcute liver failure (ALF) is a rare and life-threatening condition characterized by rapid deterioration of liver function and often requires urgent liver transplantation (LT). This study aimed to evaluate donor and recipient factors associated with 30-day mortality after LT for ALF.

methodsMedical records of patients who underwent LT for ALF at seven Brazilian transplant centers were reviewed. Patient data were obtained from electronic medical records. The primary outcome was 30-day mortality after LT.

resultsNinety patients who underwent LT for ALF were included. Thirty-day mortality occurred in 46 of 90 patients (51%). In multivariable analysis, higher pretransplant serum creatinine levels (OR 3.49, 95% CI 1.69-8.72; p = 0.003) and the need for mechanical ventilation prior to transplantation (OR 5.46, 95% CI 1.21-28.9; p = 0.033) were independently associated with early mortality. Donor age ≥ 50 years and pretransplant vasoactive drug use were associated with mortality in univariate analysis.

conclusionHigher pretransplant serum creatinine levels and the need for mechanical ventilation were independently associated with 30-day mortality, whereas donor age ≥ 50 years and pretransplant vasoactive drug use were associated with mortality only in the univariate analysis. These findings support improved pretransplant risk stratification and perioperative management in patients undergoing LT for ALF.

Indexed as

Liver Failure, AcuteLiver TransplantationAdultAge FactorsBrazilCohort StudiesCreatinineFemaleHumansMaleMiddle AgedRespiration, ArtificialRetrospective StudiesRisk FactorsTissue DonorsCreatinineacute liver failureliver transplantationmortality predictors

Identifiers

PMID42675878
PMCPMC13530867

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.