Evidence map›Paper›PMID 42675867›Full record

ArticleFEBS open bio2026

Cell surface CD11c as a neutrophil aging marker molecule.

Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y Kim, Koichi Yuki

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FEBS open bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sophia KoutsogiannakiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts, USA.
Fahd AlhamdanDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts, USA.
Erik MalmDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts, USA.
Marie BermudezDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts, USA.
Samuel Y KimDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts, USA.
Koichi YukiDepartment of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Massachusetts, USA.ORCID https://orcid.org/0000-0003-1312-585X

Funding

CD11c as a novel target to improve neutrophil effector functions and sepsis outcomeR01GM148392 · NIGMS · BOSTON CHILDREN'S HOSPITAL · PI Koichi Yuki · 2023 to 2026
$1.5M
Neutrophil-mediated multiple organ dysfunction during sepsisR21HD099194 · NICHD · BOSTON CHILDREN'S HOSPITAL · PI KOUTSOGIANNAKI, SOPHIA, YUKI, KOICHI · 2020 to 2021
$487k
Eunice Kennedy Shriver National Institute of Child Health and Human Development R21HD099194NICHD NIH HHS R21 HD099194NIGMS NIH HHS R01 GM148392NIGMS NIH HHS R01GM148392
6 · The paper itself

Abstract

Neutrophils exhibit substantial functional heterogeneity shaped by both developmental stage and cellular maturation, but their mechanisms remain incompletely defined. CD11c (ITGAX) is traditionally considered as a cell surface marker of dendritic cells. We recently reported that it is highly expressed intracellularly in neutrophils and contributes to their maturation; however, its role at the cell surface is unclear. Here, we showed that surface CD11c expression level was heterogeneous across neutrophils, enabling classification into CD11c

Indexed as

CD11ccell surfaceIntegrinneutrophils

Identifiers

PMID42675867
PMCPMC13530437

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.