Evidence map›Paper›PMID 42675814›Full record

ArticleThe New phytologist2026

High-variance phenome database reveals important roles of WD40 proteins in the plant pathogenic fungus Fusarium graminearum.

Soyoung Choi, Nahyun Lee, Jiyeun Park, Hosung Jeon, Sieun Kim, Jung-Eun Kim, Jiyoung Shin, Heeji Moon, Kyunghun Min, Yejin Choi and 6 more

Abstract read
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In one paragraph

Article in The New phytologist, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

16 authors.

Soyoung Choi *Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Nahyun Lee *Department of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.ORCID https://orcid.org/0009-0002-9586-0400
Jiyeun ParkDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.ORCID https://orcid.org/0000-0003-1179-4574
Hosung JeonDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Sieun KimDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Jung-Eun KimHorticultural and Herbal Crop Environment Division, National Institute of Horticultural and Herbal Science, Rural Development Administration, Wanju, 55365, Republic of Korea.
Jiyoung ShinDivision of Bioresources Bank, Honam National Institute of Biological Resources, Mokpo, 58762, Republic of Korea.
Heeji MoonDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Kyunghun MinDepartment of Microbiology, Pukyong National University, Busan, 48513, Republic of Korea.
Yejin ChoiDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Aram HwangboDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Hun KimCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Gyung Ja ChoiCenter for Eco-friendly New Materials, Korea Research Institute of Chemical Technology, Daejeon, 34114, Republic of Korea.
Yin-Won LeeDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.
Dae-Geun SongNatural Product Informatics Research Center, Korea Institute of Science and Technology (KIST) Gangneung Institute of Natural Products, Gangneung, 25451, Republic of Korea.ORCID https://orcid.org/0000-0003-0471-8602
Hokyoung SonDepartment of Agricultural Biotechnology, Seoul National University, Seoul, 08826, Republic of Korea.ORCID https://orcid.org/0000-0001-5080-7951

Funding

Korea Institute of Science and Technology Grand Challenge/26Z0001Ministry of Agriculture, Food and Rural Affairs RS-2024-00398300National Research Foundation of Korea RS-2025-00553624
6 · The paper itself

Abstract

WD40 is a highly conserved protein domain in eukaryotes that functions as a versatile platform for protein-protein interactions and participates in diverse biological processes. We performed a genome-wide functional analysis of WD40 domain-containing proteins in Fusarium graminearum, a phytopathogenic fungus that causes severe yield losses and mycotoxin contamination in major cereal crops. Comprehensive phenotypic profiling of 119 WD40 gene deletion mutants across 22 phenotypic traits established a systematic WD40 phenome dataset, revealing the broad functional involvement of WD40 proteins and a strong correlation between sexual reproduction and virulence. Protein interaction analyses of selected WD40 proteins revealed diverse WD40-mediated interaction patterns and provided further insights into WD40-mediated protein interactions and their roles in protein complex formation. This study provides a foundation for further characterization of WD40 proteins in filamentous fungi.

Indexed as

Databases, GeneticFungal ProteinsFusariumPlant DiseasesWD40 RepeatsGene DeletionMutationPhenotypeVirulenceFungal Proteinsaffinity purification‐mass spectrometry (AP‐MS)fungiFusarium graminearumimmunoprecipitation (IP)sexual developmentvirulenceWD40

Identifiers

PMID42675814
PMCPMC13628547

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