ArticleBasic & clinical pharmacology & toxicology2026
Hypotonicity-Induced WNK1 Phosphorylation Prevents H
Yajuan Zhang, Wei Lin, Fengting Lu, Zhujun Liang, Chengcui Huang, Ma Mingming, Liang Sijia, Pang Ruiping, Jiaguo Zhou, Yongyuan Guan and 2 more
Abstract read
In one paragraphArticle in Basic & clinical pharmacology & toxicology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
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4 · The recordCorrections and comments
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5 · Who and what moneyAuthors and funding
12 authors.
Yajuan ZhangDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Wei LinDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Chengcui HuangDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Pang RuipingDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Jiaguo ZhouDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Yongyuan GuanDepartment of Pharmacology, Cardiac and Cerebral Vascular Research Center, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, Guangdong, China.
Funding
National Natural Science Foundation of China 81903598National Natural Science Foundation of China 82473916Natural Science Foundation of Jiangsu Province BK20250354
6 · The paper itselfAbstract
Vascular smooth muscle cells (VSMCs) are essential for maintaining arterial wall integrity, with their associated apoptosis critically involved in cardiovascular diseases. Intracellular chloride anion (Cl
Indexed as
ApoptosisHydrogen PeroxideMuscle, Smooth, VascularMyocytes, Smooth MuscleWNK Lysine-Deficient Protein Kinase 1AnimalsChloride ChannelsChloridesHypotonic SolutionsMembrane Potential, MitochondrialPhosphorylationProto-Oncogene Proteins c-bcl-2Signal TransductionChloride ChannelsChloridesHydrogen PeroxideHypotonic SolutionsProto-Oncogene Proteins c-bcl-2WNK Lysine-Deficient Protein Kinase 1A10 cellscell apoptosishypotonic solutionvascular smooth muscle cellsWNK1
Identifiers
PMID42675813
PMCPMC13530421
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