Observational studyMedicine2026
Analysis of duodenal ulcer mortality trends by sex, race, age, and region in the United States, 1999-2023: A CDC WONDER database study.
Observational study in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To systematically evaluate long-term trends in duodenal ulcer (DU)-related mortality in the United States (US) from 1999 to 2023 using US Centers for Disease Control and Prevention, Wide-ranging Online Data for Epidemiologic Research mortality registry data and to identify disparities by sex, race/ethnicity, age, region, and urban-rural setting, a retrospective population-based study design was employed. DU-related deaths were identified using International Classification of Diseases, 10th Revision code K26. Annual death counts were extracted, and age-adjusted mortality rates were calculated using the 2000 US standard population. Joinpoint regression (with Monte Carlo permutation testing) estimated annual percentage changes (APCs) and average APCs, reporting 95% confidence intervals. From 1999 to 2023, a total of 34,520 cumulative DU-related deaths occurred in the US The overall age-adjusted mortality rate declined from 0.83 to 0.64 per 100,000 (average APC = -1.32; 95% confidence interval = -2.75-0.14), with a marked decrease through 2009 followed by flattening and signs of resurgence thereafter. This "decline-then-rise" pattern was most evident among men, older adults (≥ 65 years), several racial and ethnic groups (including non-Hispanic White, Hispanic, and other races), and across all 4 census regions, while nonmetropolitan areas consistently had higher age-adjusted mortality rates than metropolitan areas. State-level analyses showed generally declining mortality with recent rebounds in several states. Over the past 2 decades, DU-related mortality in the US has generally declined. However, the rate of decline slowed around 2010, with rebounds occurring in certain populations. Persistent inequalities persist across sex, race/ethnicity, geographic regions, and urban/rural settings. Future public health strategies should implement stratified, targeted interventions for elderly and high-risk medication populations to reduce disparities and address emerging challenges.
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Registered trials
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