Evidence map›Paper›PMID 42675689›Full record

ArticleMedicine2026

Rare circle of Willis variants associated with multiple intracranial aneurysms and subarachnoid hemorrhage: A case report.

Mohamad H Mosi, Hisham Alfarra, Nawwar Soliman, Moaaz Khalouf Alshaar, Mahmoud Khalouf Alshaar, Ghassan Hamzeh

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In one paragraph

Article in Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Mohamad H MosiDepartment of Internal Medicine, National University Hospital and Al Mouwasat University Hospitals, Damascus University, Faculty of Medicine, Damascus, Syria.ORCID 0009-0007-4406-6393
Hisham AlfarraDepartment of Radiology, Hama National Hospital, Hama, Syria.ORCID 0009-0006-3957-2681
Nawwar SolimanDepartment of Internal Medicine, National University Hospital and Al Mouwasat University Hospitals, Damascus University, Faculty of Medicine, Damascus, Syria.
Moaaz Khalouf AlshaarFaculty of Medicine, Hama University, Hama, Syria.
Mahmoud Khalouf AlshaarDepartment of Pathology, Hama National Hospital, Hama, Syria.
Ghassan HamzehDepartment of Neurology, National University Hospital, Damascus University, Faculty of Medicine, Damascus, Syria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

rationaleSubarachnoid hemorrhage from a ruptured intracranial aneurysm is a type of stroke with high rates of mortality and disability, and the prevalence of aneurysm formation increases in the presence of Circle of Willis variants. PATIENT CONCERNS: A 64-year-old man with a history of hypertension and psoriatic arthritis presented with a sudden severe headache and walking difficulties without any loss of consciousness. DIAGNOSES: Non-contrast computed tomography showed a diffuse subarachnoid hemorrhage. Computed tomography angiography demonstrated multiple intracranial aneurysms together with variants of the posterior communicating artery and posterior cerebral artery, which may have contributed to aneurysm formation.

interventionsThe patient was started on oral Nimodipine to prevent cerebral vasospasm and underwent stent-assisted coil embolization of the ruptured aneurysm. OUTCOMES: His symptoms and clinical condition improved a few days after the embolization, and he was discharged after 18 days. LESSONS: This is the first documented case report from Syria, and possibly the first ever, detailing such Circle of Willis variants associated with cerebral aneurysms. It underscores the need for further studies exploring the relationship between the type of variants and the number and size of cerebral aneurysms, which is important for a better understanding of the epidemiology of cerebral aneurysms.

Indexed as

Aneurysm, RupturedCircle of WillisIntracranial AneurysmSubarachnoid HemorrhageComputed Tomography AngiographyEmbolization, TherapeuticHumansMaleMiddle AgedNimodipineSyriaNimodipineCircle of Willisposterior cerebral arteryposterior communicating arteryruptured aneurysmsubarachnoid hemorrhage

Identifiers

PMID42675689
PMCPMC13529132

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.