ArticleAdvanced science (Weinheim, Baden-Wurttemberg, Germany)2026
An Injectable Metal-Drug Supramolecular Condensate Enables Radiosensitization and Systemic Antitumor Immunity for Post-Surgical Osteosarcoma Therapy.
Tianhua Xiao, Zunlei Gong, Chuke Chen, Hui Yu, Yu Cai, Can Liu, Hongkai Huang, Ying Li, Jinyuan Guan, Le Wang and 3 more
Abstract read
In one paragraphArticle in Advanced science (Weinheim, Baden-Wurttemberg, Germany), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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5 · Who and what moneyAuthors and funding
13 authors.
Zunlei Gong *Department of Orthopaedic Surgery, Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chuke Chen *Department of Orthopaedic Surgery, Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Hui YuDepartment of Orthopaedic Surgery, Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0003-4573-5484 Yu CaiDepartment of Orthopaedic Surgery, Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Ying LiSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Jinyuan GuanSchool of Chemical Engineering and Light Industry, Guangdong University of Technology, Guangzhou, China.
Le WangDepartment of Orthopaedic Surgery, Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.
Chengyun NingSchool of Materials Science and Engineering, National Engineering Research Center for Tissue Restoration and Reconstruction, South China University of Technology, Guangzhou, China.
Lei ZhouDepartment of Orthopaedic Surgery, Guangzhou Key Laboratory of Spine Disease Prevention and Treatment, The Third Affiliated Hospital, Guangzhou Medical University, Guangzhou, China.ORCID https://orcid.org/0000-0001-8056-9464 Funding
Guangdong Basic and Applied Basic Research Foundation 2025A1515011844Guangdong Basic and Applied Basic Research Foundation 2025A1515011845Guangdong Basic and Applied Basic Research Foundation 2026A1515012309National Natural Science Foundation of China 110205613National Natural Science Foundation of China 32471431National Natural Science Foundation of China 52533013National Natural Science Foundation of China U22A20160Science and Technology Plan Project of Guangzhou City 2025A04J3679
6 · The paper itselfAbstract
Radiotherapy (RT) is widely used as an adjuvant treatment after surgical resection for osteosarcoma, but its efficacy is often limited by insufficient radiosensitization and an immunosuppressive tumor microenvironment that restricts systemic antitumor immunity and promotes recurrence and metastasis. Here we report an injectable metal-drug supramolecular condensate formed from hafnium ions and alendronate (Hf-ALN) and loaded with the COX-2 inhibitor celecoxib (CXB) for synergistic radioimmunotherapy of postoperative osteosarcoma. The condensate forms through coordination-driven liquid-liquid phase separation between Hf
Indexed as
immune microenvironment reprogrammingimmunogenic cell deathmetal‐drug supramolecular condensateosteosarcomaradiotherapy sensitizationrecurrence and metastasis
Identifiers
PMID42675587
PMCPMC13530022
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