Evidence map›Paper›PMID 42675576›Full record

ArticleChemMedChem2026

Identification of New Putative Autotaxin Inhibitors via Structure-Based Virtual Screening and Evaluation of Their Antiproliferative Properties Against Ovarian and Breast Cancer Cells.

Angelina Boccarelli, Adriana Coricello, Francesca Alessandra Ambrosio, Valentina Leo, Salvatore Mirabile, Rosaria Gitto, Modesto de Candia, Marco Catto, Francesco Ortuso, Cosimo D Altomare and 1 more

Abstract read
In one paragraph

Article in ChemMedChem, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Angelina BoccarelliDepartment of Precision and Regenerative Medicine and Ionian Area, School of Medicine, Section of General Pathology, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0002-9514-2022
Adriana CoricelloDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Catanzaro, Italy.
Francesca Alessandra AmbrosioDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0003-4874-2946
Valentina LeoDepartment of Precision and Regenerative Medicine and Ionian Area, School of Medicine, Section of General Pathology, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0003-3368-5133
Salvatore MirabileDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.ORCID https://orcid.org/0009-0004-1882-5016
Rosaria GittoDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Messina, Italy.
Modesto de CandiaDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy.
Marco CattoDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0002-8411-304X
Francesco OrtusoDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0001-6235-8161
Cosimo D AltomareDepartment of Pharmacy-Pharmaceutical Sciences, University of Bari Aldo Moro, Bari, Italy.ORCID https://orcid.org/0000-0001-5016-5805
Stefano AlcaroDipartimento di Scienze della Salute, Università "Magna Græcia" di Catanzaro, Catanzaro, Italy.ORCID https://orcid.org/0000-0002-0437-358X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Autotaxin (ATX), a lysophospholipase D playing an important role in several inflammatory diseases, as well as in tumor invasion, progression, and metastasis, is an attractive therapeutic target. Herein, we report a virtual screening study of an in-house molecular database. In silico simulations highlighted five putative ATX inhibitors. The enzyme assay showed that compound 3 achieves inhibition potency in the submicromolar range (IC

Indexed as

Antineoplastic AgentsBreast NeoplasmsEnzyme InhibitorsOvarian NeoplasmsPhosphoric Diester HydrolasesAnimalsCell Line, TumorCell ProliferationDose-Response Relationship, DrugDrug Screening Assays, AntitumorFemaleHumansLysophospholipase DMiceMolecular Docking SimulationMolecular StructureAntineoplastic AgentsEnzyme InhibitorsLysophospholipase DPhosphoric Diester Hydrolasesautotaxincancerheterocyclic small moleculesPRIN SUD Virtual Chemothecavirtual screeningwound‐healing assay

Identifiers

PMID42675576
PMCPMC13530303

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.