Evidence map›Paper›PMID 42675502›Full record

ReviewTranslational neurodegeneration2026

Phase separation in neurodegenerative disorders: a metabolic perspective on protein aggregation and therapeutic targeting.

Shujun Peng, Hui Chen, Guowei Yin, Alexei Verkhratsky, Chenju Yi

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Translational neurodegeneration, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Shujun PengDepartment of Geriatrics, Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, China.
Hui ChenSchool of Life Sciences, Faculty of Science, University of Technology Sydney, Sydney, Australia.
Guowei YinDepartment of Geriatrics, Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, China. yingw3@mail.sysu.edu.cn.
Alexei VerkhratskyFaculty of Biology, Medicine and Health, The University of Manchester, Manchester, UK. Alexej.Verkhratsky@manchester.ac.uk.
Chenju YiDepartment of Geriatrics, Seventh Affiliated Hospital of Sun Yat-Sen University, Shenzhen, 518107, China. yichj@mail.sysu.edu.cn.ORCID https://orcid.org/0000-0002-8686-4525

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Biomolecular condensates formed via liquid-liquid phase separation (LLPS) are increasingly recognised as dynamic organisers of intracellular biochemistry, particularly in neurons where spatially restricted signalling, RNA metabolism, and proteostasis are essential. Aberrant phase transitions of disease-associated proteins, including TDP-43, FUS, tau, and α-synuclein, contribute to protein aggregation and neurodegenerative pathology. Beyond protein-intrinsic sequence features, metabolic state has emerged as an important contextual regulator of condensate assembly, material properties, and liquid-to-solid maturation. Metabolic cues, including ATP availability, NAD

Indexed as

Biomolecular CondensatesNeurodegenerative DiseasesProtein AggregatesProtein Aggregation, PathologicalAnimalsHumansNeuronsPhase SeparationProtein AggregatesCognitionMetabolic enzymesNeurodegenerative diseasesPathological protein aggregationPhase separation

Identifiers

PMID42675502
PMCPMC13528016

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.