ArticleBMC health services research2026
A scoping review and systems thinking synthesis of scale-up frameworks.
Article in BMC health services research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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4 authors.
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Abstract
backgroundThere is a pressing need to scale-up health and human services. While there are many scale-up frameworks in the broader literature, most of the general scale-up frameworks treat scale-up as a linear process. There are calls to bolster research viewing scale-up as a dynamic process. The purpose of this review is to consolidate and apply systems thinking to existing scale-up frameworks to illustrate feedback relationships among the drivers of scale-up.
methodsWe used a scoping review informed by hermeneutic principles to search the literature for scale-up determinants. We searched six scholarly databases (Medline, Web of Science, Embase, CINAHL, PsycInfo, and Google Scholar) for review articles of scale-up frameworks that yielded key determinants of scale-up. We also included other scale-up papers that yielded determinants. Articles that did not meet these criteria were excluded during the title/abstract and full-text screening process. Two coders assessed each article before it was excluded. Two coders extracted the scale-up determinants and definitions. We used thematic analysis to code and consolidate the determinants. Then we used an ex-post development approach to create a causal loop diagram (CLD) visualizing the scale-up determinants and feedback structures.
resultsOur search yielded 2693 articles which resulted in a usable sample of 40 articles after the screening process. The 40 articles contained 1053 scale-up determinants. Our coding procedures and CLD reduced these determinants to 25 in our model. There are six reinforcing loops and three balancing loops that are at play in scale-up efforts depicted in the final CLD. Among the determinants, motivation, capacity, enabling environment, and alignment were prominent.
conclusionsThe resulting interpretation and CLD provide a dynamic conceptualization of scale-up complexity, highlighting key leverage points in the scale-up process.
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