Evidence map›Paper›PMID 42675468›Full record

Trial reportBMC psychiatry2026

Inhibitory neurotransmission in frontostriatal circuitry: implications for psychomotor and vegetative symptoms in depressive episodes.

Linda Steinholtz, Jonas Persson, Elin Thörnblom, Anders Wall, Mark Lubberink, David Fällmar, Robert Bodén

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in BMC psychiatry, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Linda SteinholtzDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden. linda.steinholtz@uu.se.ORCID https://orcid.org/0000-0001-9008-9763
Jonas PerssonDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Elin ThörnblomDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.
Anders WallDepartment of Surgical Sciences, Molecular Imaging and Medical Physics, Uppsala University, Uppsala, Sweden.
Mark LubberinkDepartment of Surgical Sciences, Molecular Imaging and Medical Physics, Uppsala University, Uppsala, Sweden.
David FällmarDepartment of Surgical Sciences, Neuroradiology, Uppsala University, Uppsala, Sweden.
Robert BodénDepartment of Medical Sciences, Uppsala University, Uppsala, Sweden.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundGamma-aminobutyric acid (GABA) dysfunction has been implicated in depression, although research findings remain inconsistent. This may indicate that distinct biological mechanisms underlie different symptom profiles in depressive episodes. Altered GABA function might be especially relevant in cases characterised by psychomotor retardation and vegetative symptoms, which are prominent in melancholia. This study aimed to investigate if such melancholic features are related to GABA levels or GABA

methodsThis was a secondary analysis of data obtained from a randomised controlled trial. Forty-two patients with either bipolar or unipolar depression were assessed before and after a course of repetitive transcranial magnetic stimulation. GABA and glutamate levels in the dorsal anterior cingulate cortex (dACC) were measured using a [

resultsThe findings did not establish that psychomotor or vegetative symptoms were associated with GABA levels or GABA

conclusionsTo better understand the relationship between GABA dysfunction and melancholic features, future studies should ideally focus on patients exhibiting more pronounced psychomotor and vegetative symptoms and examine additional cortical regions.

Indexed as

Corpus StriatumDepressive Disordergamma-Aminobutyric AcidGyrus CinguliPsychomotor DisordersSynaptic TransmissionAdultBasal GangliaBipolar DisorderFemaleGlutamic AcidHumansHypothalamusMagnetic Resonance SpectroscopyMaleMiddle Agedgamma-Aminobutyric AcidGlutamic AcidReceptors, GABA-ABasal gangliaBipolar disorderMajor depressive disorderTerminal insomnia

Identifiers

PMID42675468
PMCPMC13531897

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.