Trial reportBMC anesthesiology2026
Norepinephrine infusion for prophylaxis against spinal-induced hypotension in elderly patients undergoing hip surgery: a randomized controlled comparison of two doses.
Trial report in BMC anesthesiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT07077265 (Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in Elderly Patients Undergoing Hip Surgery), which is not on this map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Comparing Two Different Norepinephrine Infusion Rates for Prophylaxis Against Spinal-induced Hypotension in Elderly Patients Undergoing Hip Surgery: A Randomized Controlled Non-inferiority Trial
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundWe aimed to compare the hemodynamic response to two norepinephrine infusion rates for prophylaxis against post-spinal hypotension in elderly population undergoing hip surgery.
methodsThis randomized non-inferiority clinical trial included elderly patients scheduled for hip surgery under spinal anesthesia. Patients received norepinephrine infusion at a rate of 0.1 mcg/kg/min (0.1-mcg group) or 0.07 mcg/kg/min (0.07-mcg group) after spinal anesthesia. Intraoperative mean arterial pressure (MAP) and heart rate were recorded every 2 min for 46 min after spinal anesthesia. The primary outcome was the noninferiority comparison between the two groups regarding the average MAP readings. Non-inferiority was declared if the average post-spinal MAP in the 0.07-mcg group was within 8 mmHg of the 0.1-mcg group. Secondary outcomes were incidence of post-spinal hypotension (MAP < 70% of baseline or < 65 mmHg), bradycardia, and hypertension. The secondary outcomes were assessed for superiority.
resultsEighty-four patients were analyzed. The average intraoperative MAP was 87.9 ± 9.5 mmHg in the 0.1-mcg group and 84.5 ± 8.5 mmHg in the 0.07-mcg group, with a mean difference of -3.5 mmHg (95% confidence interval: -7.4 to 0.4 mmHg) and the lower bound of the 95% confidence interval did not cross the prespecified non-inferiority margin. The incidence of hypotension, hypertension, and bradycardia was comparable between the two groups.
conclusionIn elderly patients undergoing hip surgery under spinal anesthesia, a norepinephrine infusion rate of 0.07 mcg/kg/min was not inferior to 0.1 mcg/kg/min in maintaining post-spinal MAP. Both infusion rates had comparable profile regarding adverse events, namely reactive hypertension and bradycardia. CLINICAL
trial registrationClinicalTrials.gov identifier NCT07077265. URL: https://www. CLINICALTRIALS: gov/study/NCT07077265?term=NCT07077265&rank=1 .
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