Evidence map›Paper›PMID 42675451›Full record

ArticleJournal of food science2026

Biogenic Silver Nanoparticles Mediated by Phytoconstituents of the Edible Spice Pimpinella anisum: Characterization and In Vitro, In Vivo, and In Silico Biological Evaluation.

Ibtissam Laib, Anis Ben Ali, Soundes Guedda, Nardjes Guedda, Naglaa A Abd-Elkarim, Yousef Benaissa, Nariman Essmat, Elhafnaoui Lanez, Mohamed F Abouelenein, Ahmed I Osman and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Ibtissam LaibDepartment of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
Anis Ben AliDepartment of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
Soundes GueddaDepartment of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
Nardjes GueddaDepartment of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
Naglaa A Abd-ElkarimDepartment of Food and Dairy Sciences, Faculty of Agriculture, Qena University, Qena, Egypt.
Yousef BenaissaVPRS Laboratory, Chemistry Department, Faculty of Mathematics and Matter Sciences, University of KASDI Merbah, Ouargla, Algeria.
Nariman EssmatDepartment of Pharmacology and Toxicology, Faculty of Pharmacy, Zagazig University, Zagazig, Egypt.
Elhafnaoui LanezDepartment of Cellular and Molecular Biology, El Oued University, El Oued, Algeria.
Mohamed F AboueleneinDepartment of Insurance and Risk Management, College of Business, Imam Mohammad Ibn Saud Islamic University (IMSIU), Riyadh, Riyadh, Saudi Arabia.
Ahmed I OsmanSchool of Sciences, Psychology, Arts and Humanities, Computing, Engineering, and Sport, Canterbury Christ Church University, Canterbury, UK.ORCID https://orcid.org/0000-0003-2788-7839
Alaa MahfouzMedicinal and Aromatic Plants Department, Desert Research Center, Cairo, Egypt.
Ahmed K RashwanDepartment of Food and Dairy Sciences, Faculty of Agriculture, Qena University, Qena, Egypt.ORCID https://orcid.org/0000-0002-9318-5256

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study evaluated the aqueous extract of Pimpinella anisum seeds (AE-PAS) and its green-synthesized silver nanoparticles (PA-AgNPs) using integrated in vitro, in vivo, and in silico approaches. LC-MS analysis identified 26 phytoconstituents, mainly sinapic acid (15.78%), hispidulin (15.35%), caffeic acid (11.09%), and rutin (8.86%). Total phenolic and flavonoid contents were 45.2 ± 2.1 mg GAE/g DE and 28.7 ± 1.5 mg QE/g DE, respectively. UV-Vis spectroscopy, scanning electron microscopy (SEM), Fourier-transform infrared (FTIR) spectroscopy, and X-ray diffraction (XRD) supported nanoparticle formation, indicating dry-state particle or agglomerate features of approximately 60-90 nm, a surface plasmon resonance (SPR) peak at 421 nm, 50.81% crystallinity, and a crystallite-domain size of 22.57 ± 1.2 nm. AE-PAS showed measurable antioxidant and albumin-denaturation-inhibitory responses (DPPH IC

Indexed as

Metal NanoparticlesPhytochemicalsPimpinellaPlant ExtractsSilverAnimalsAnti-Bacterial AgentsAntioxidantsHemolysisMolecular Docking SimulationSeedsAnti-Bacterial AgentsAntioxidantsPhytochemicalsPlant ExtractsSilveranalgesicantidepressantanti‐inflammatoryantioxidantmolecular dockingmulti‐target therapyPimpinella anisumsilver nanoparticles

Identifiers

PMID42675451
PMCPMC13529928

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.