Comparing a Fixed and Freely Rotating Capsule in a Dry Powder Inhaler Under Realistic Breathing Conditions.

Karan Shrivastava, Ajit Kumar, Somashekhar S Hiremath, Agisilaos Kourmatzis, Gajendra Singh

Abstract read

In one paragraph

Article in Pharmaceutical research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

5 authors.

Karan ShrivastavaDepartment of Mechanical Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, 600036, India.

Ajit KumarSchool of Mechanical and Materials Engineering, IIT Mandi, Mandi, HP, 175075, India.

Somashekhar S HiremathDepartment of Mechanical Engineering, Indian Institute of Technology Madras, Chennai, Tamil Nadu, 600036, India.

Agisilaos KourmatzisSchool of Aerospace, Mechanical and Mechatronic Engineering, The University of Sydney, Sydney, NSW, 2006, Australia.

Gajendra SinghSchool of Mechanical and Materials Engineering, IIT Mandi, Mandi, HP, 175075, India. gajendra@iitmandi.ac.in.ORCID http://orcid.org/0000-0001-6683-8680

Funding

ANRF SRG/2022/000171

6 · The paper itself

Abstract

purposeTo investigate the performance of a capsule-based dry powder inhaler (DPI) under two device configurations - free-axis and fixed-axis capsule rotation - across steady-state and transient inhalation profiles.

methodTwo new research-based transparent capsule-based DPI were developed-one with a fixed capsule rotational axis and another with a floating capsule configuration. High-speed imaging was used to capture capsule motion, and the effects of flow regimes (laminar, transient, and turbulent), capsule rotation, and breathing profiles on capsule RPM, wall collisions, and powder retention were analyzed.

conclusionsFixed-axis rotation significantly outperformed free-axis rotation (~ 6 × higher RPM and lower powder retention). Higher flow rates and faster-accelerating transient profiles increased RPM and collision frequency, enhancing drug release. Fixing the rotational axis of the capsule had the greatest benefit for the slow inhalation profile. The findings offer key insights for the design of future capsule-based DPIs.

Indexed as

DPIfixed-axis cDPIfree-axis cDPIpowder evacuationtransient inhalation

Identifiers

PMID42675374

DOI10.1007/s11095-005-6155-x

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.