ArticleJournal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine2026
Oxygen overshoot burden of central sleep apnea and its association with cardiovascular outcomes.
Article in Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Above the line: oxygen overshoot in the oximetry trace.Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine · 2026Article
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6 authors.
Funding
Abstract
purposeThe role of oxidative stress in central sleep apnea (CSA) remains unknown. We examined whether "oxygen overshoot burden"-a measure of cumulative oxygen saturation levels above baseline-is associated with major adverse cardiovascular events (MACE) in CSA.
methodsWe analyzed 7530 participants from the Sleep Heart Health Study (SHHS; age 64 years; 47.0% male) and the Osteoporotic Fractures in Men Study (MrOS; age 76 years; 100% male). Oxygen overshoot burden was defined as the area under the SpO
resultsOver a follow-up of 8.92 years, 2258 MACE events occurred. Oxygen overshoot burden (continuous) was associated with increased MACE risk, with stronger associations among individuals with any central apneas (p = 0.003 and p = 0.02 for sleep and wakefulness baselines, respectively). In secondary analyses, participants with CSA and high oxygen overshoot burden had higher MACE incidence (54.6%) than controls (25.6%; HR 1.45 [95%CI = 1.16,1.82]; p = 0.001). In contrast, CSA with low oxygen overshoot burden and OSA with high or low oxygen overshoot burden showed MACE risk comparable to controls. Results were robust to adjustment for AHI, central apnea index, loop gain, and hypoxic burden.
conclusionsOxygen overshoot burden in CSA is independently associated with increased MACE risk and may improve risk stratification in sleep-disordered breathing. These findings require validation in larger, more diverse populations given sample limitations and potential pulse oximetry bias across skin pigmentation. CURRENT KNOWLEDGE/STUDY RATIONALE: Oxidative stress may contribute to cardiovascular risk in central sleep apnea (CSA), but the clinical significance of post-apneic oxygen overshoot is unknown. We examined whether oxygen overshoot burden, representing cumulative oxygen saturation above baseline, is associated with major adverse cardiovascular events (MACE). STUDY IMPACT: Greater oxygen overshoot burden was associated with increased cardiovascular risk in individuals with central sleep apnea but not in those with obstructive sleep apnea. These findings identify a potential high-risk central sleep apnea phenotype and suggest that oxygen overshoot burden may improve cardiovascular risk stratification and inform future mechanistic and interventional studies.
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