Alpikwangsides A-C, three previously undescribed compounds isolated from the rhizomes of Alpinia kwangsiensis and their NO inhibitory activity.

Nguyen Thi Mai, Bui Thi Mai Anh, Tran Thuy Nga, Le Thi Huyen, Nguyen Vu Minh Tam, Nguyen Huy Hoang, Nguyen Viet Dung, Nguyen Phuong Thao

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Article in Journal of natural medicines, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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Authors and funding

8 authors.

Nguyen Thi MaiBasic Science Department, University of Transport and Communications, 3 Cau Giay, Lang, Hanoi, Vietnam.

Bui Thi Mai AnhBasic Science Department, University of Transport and Communications, 3 Cau Giay, Lang, Hanoi, Vietnam.

Tran Thuy NgaBasic Science Department, University of Transport and Communications, 3 Cau Giay, Lang, Hanoi, Vietnam.

Le Thi HuyenFaculty of Chemistry, Vietnam National University Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.

Nguyen Vu Minh TamFaculty of Chemistry, Vietnam National University Hanoi, 334 Nguyen Trai, Thanh Xuan, Hanoi, Vietnam.

Nguyen Huy HoangInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.

Nguyen Viet DungInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam.

Nguyen Phuong ThaoInstitute of Chemistry, Vietnam Academy of Science and Technology (VAST), 18 Hoang Quoc Viet, Nghia Do, Hanoi, Vietnam. thaonp@ich.vast.vn.ORCID http://orcid.org/0000-0002-8793-2593

Funding

National Foundation for Science and Technology Development 104.01-2023.30

6 · The paper itself

Abstract

Three previously undescribed compounds, alpikwangsides A-C (1-3), together with 10 known compounds (4-13), were isolated from the rhizomes of Alpinia kwangsiensis (Zingiberaceae). Their structures were elucidated by 1D and 2D NMR spectroscopy and HRESIMS data, and the absolute configuration of compound 3 was assigned based on ECD analysis. Coronarin G (6) is reported from the genus Alpinia for the first time, whereas pahangensin B (7) is identified for the first time from this species. Biological evaluation showed that compounds 1-3, 7, and 8 inhibited LPS-induced NO production in RAW264.7 cells, with IC

Indexed as

Alpinia kwangsiensisDiarylheptanoidLabdane diterpenoidNO inhibitory activityZingiberaceae

Identifiers

PMID42675345

DOI10.1002/cbdv.202401679

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.