Evidence map›Paper›PMID 42675329›Full record

ArticleDaru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences2026

Antifungal activities and toxicity studies of water-soluble non-steroidal analgesic salts.

Julian Gonzalo Arrieta, Natali Ivana Carrizo, Franco Augusto Aguilar, Guillermo Antonio Garcia Pitalluga, Diego Alejandro Sampietro, Melina Araceli Sgariglia, José Rodolfo Soberón

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Julian Gonzalo ArrietaCatedra de Fitoquimica, Facultad de Bioquimica, Quimica y Farmacia, National University of Tucumán, San Miguel de Tucumán, Argentina.
Natali Ivana CarrizoCatedra de Fitoquimica, Facultad de Bioquimica, Quimica y Farmacia, National University of Tucumán, San Miguel de Tucumán, Argentina.
Franco Augusto AguilarCatedra de Fitoquimica, Facultad de Bioquimica, Quimica y Farmacia, National University of Tucumán, San Miguel de Tucumán, Argentina.
Guillermo Antonio Garcia PitallugaLaboratorio Garcia, San Nicolás de los Arroyos, Buenos Aires, Argentina.
Diego Alejandro SampietroCatedra de Fitoquimica, Facultad de Bioquimica, Quimica y Farmacia, National University of Tucumán, San Miguel de Tucumán, Argentina.
Melina Araceli SgarigliaCatedra de Fitoquimica, Facultad de Bioquimica, Quimica y Farmacia, National University of Tucumán, San Miguel de Tucumán, Argentina.
José Rodolfo SoberónCatedra de Fitoquimica, Facultad de Bioquimica, Quimica y Farmacia, National University of Tucumán, San Miguel de Tucumán, Argentina. jrsrody@yahoo.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundThe emergence of antifungal resistance among Candida albicans strains poses a growing clinical challenge, underscoring the urgent need for alternative therapeutic strategies. Drug repositioning of non-steroidal anti-inflammatory drugs (NSAIDs) has attracted attention due to their reported antimicrobial properties and well-established safety profiles.

objectivesThis study aimed to synthesize and characterize water-soluble sodium salts of ibuprofen (IBU-Na), ketoprofen (KET-Na), and indomethacin (IM-Na), and to evaluate their antifungal activity and toxicity profiles, individually and in combination with fluconazole (FLU), against C. albicans strains.

methodsNSAID sodium salts were synthesized and characterized, and their antifungal activity, synergistic interactions with FLU, and toxicity profiles were evaluated against FLU-susceptible and -resistant C. albicans strains.

resultsIBU-Na and KET-Na exhibited inhibitory and fungicidal activities against both FLU-susceptible and -resistant C. albicans strains, whereas IM-Na was inactive. Combination assays revealed strong synergistic interactions with FLU (FICI = 0.008-0.009), resulting in marked reductions in fungal viability. Neither hemolytic activity nor genotoxic effects were detected at the tested concentrations.

conclusionsWater-soluble NSAID salts, particularly IBU-Na, demonstrate potent synergistic antifungal activity with FLU and favorable safety profiles, supporting their potential as candidates for antifungal drug repurposing. These findings emphasize the importance of reassessing sodium salt derivatives rather than assuming equivalence with their acidic precursors.

Indexed as

Antifungal AgentsAnti-Inflammatory Agents, Non-SteroidalCandida albicansIbuprofenIndomethacinKetoprofenDrug Resistance, FungalDrug SynergismFluconazoleHumansMicrobial Sensitivity TestsSaltsSolubilityWaterAntifungal AgentsAnti-Inflammatory Agents, Non-SteroidalFluconazoleIbuprofenIndomethacinKetoprofenSaltsWaterAntifungal activityCandida albicansDrug repositioningNSAID saltsSynergistic effect

Identifiers

PMID42675329
PMCPMC13530096

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.