Evidence map›Paper›PMID 42675313›Full record

ArticleGeroScience2026

Association between body roundness index and progression of cardio-renal-metabolic diseases using multistate models.

Xinyi Lu, Jieru Cai, Xingge Li, Lulu Pan, Huiling Shi, Yajing Zhou, Yilin Chen, Wei Chen, Guoyou Qin, Yiqian Xu and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in GeroScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Xinyi LuDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China.
Jieru CaiDepartment of Nephrology, Zhongshan Hospital, Fudan University, Shanghai, China.
Xingge LiDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China.
Lulu PanDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China.
Huiling ShiDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China.
Yajing ZhouDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China.
Yilin ChenSchool of Health Sciences, The University of Manchester, Manchester, UK.
Wei ChenDepartment of Neurosurgery, Vascular Disease Unit, Shengli Oil‑field Central Hospital, Shandong, China.
Guoyou QinDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China.
Yiqian XuSchool of Public Health, Fudan University, Shanghai, 200032, China. xyq@fudan.edu.cn.ORCID http://orcid.org/0009-0009-3673-6347
Yongfu YuDepartment of Biostatistics, NHC Key Laboratory for Health Technology Assessment, Key Laboratory of Public Health Safety of Ministry of Education, School of Public Health, Fudan University, Shanghai, 200032, China. yu@fudan.edu.cn.ORCID http://orcid.org/0000-0003-4208-9480

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

To investigate associations between body roundness index (BRI) and progression of cardio-renal-metabolic diseases (CRMDs). This study included 442,489 UK Biobank participants aged ≥ 40 years without CRMDs at baseline. BRI was analyzed continuously and by tertiles. Primary outcomes were first CRMD (FCRMD), cardio-renal-metabolic multimorbidity (CRMM), and all-cause mortality. Hazard ratios (HRs) and population attributable fractions (PAFs) were estimated using Cox and multistate models. Higher BRI was consistently associated with increased risks of CRMD onset and all-cause mortality, with strongest associations in the highest tertile for T2D (HR 6.94, 95% CI 6.57-7.33) and CRMM (HR 3.25[3.05-3.46]). In multistate analyses, the highest BRI tertile showed significantly higher risks for transitioning from baseline to FCRMD (HR 2.24[2.19-2.29], PAF 26.22%), from FCRMD to CRMM (HR 1.58[1.47-1.69], PAF 21.21%), and from baseline to death (HR 1.05[1.02-1.09], PAF 2.06%). Participants with higher BRI combined with high genetic risk or unhealthy lifestyle had a greater risk of CRMD onset and progression along the cardio-renal-metabolic continuum. Elevated BRI was associated with increased risks of incident CRMDs and progression to multimorbidity, supporting its potential value for early risk identification.

Indexed as

Body roundness indexCardio-renal-metabolic diseasesGenetic riskLifestyleMultimorbidity

Identifiers

PMID42675313

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.