Evidence map›Paper›PMID 42675307›Full record

GuidelineSurgical endoscopy2026

SAGES clinical practice guidelines for the management of symptomatic walled-off pancreatic necrosis.

Elisa C Calabrese, Dena Shehata, Bethany J Slater, Francesco Palazzo, Adnan Alseidi, James Sun, Edwin Onkendi, David Caba Molina, Katlin Mallette, Ansley B Ricker and 13 more

Abstract readPractice GuidelineSystematic Review
PubMed Publisher
In one paragraph

Guideline in Surgical endoscopy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

23 authors.

Elisa C CalabreseDepartment of Surgery, University of California San Francisco-East Bay, 1411 E 31st St, Oakland, CA, 94602, USA. eclbrs@gmail.com.ORCID http://orcid.org/0009-0007-0217-7933
Dena ShehataDepartment of Surgery, Lahey Hospital and Medical Center, Burlington, MA, USA.
Bethany J SlaterDepartment of Surgery, Mount Sinai Kravis Children's Hospital, New York, NY, USA.
Francesco PalazzoDepartment of Surgery, Thomas Jefferson University, Philadelphia, PA, USA.
Adnan AlseidiDepartment of Hepato-Pancreato-Biliary (HPB) Surgery & Endocrine Surgery (SFGH), University of California San Francisco-UCSF, San Francisco, CA, USA.
James SunDepartment of Surgery, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA.
Edwin OnkendiDepartment of Surgery, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
David Caba MolinaDepartment of Surgery, Riverside University Health System, Riverside, CA, USA.
Katlin MalletteDepartment of Surgery, University of Saskatchewan, Saskatoon, SK, Canada.
Ansley B RickerDepartment of Surgery, Atrium Health Carolinas Medical Center, Charlotte, NC, USA.
Subhashini AylooDepartment of Surgery, Saginaw VA Health System, Saginaw, MI, USA.
Joshua LyonsDepartment of Surgery, University Hospitals, Case Western Reserve University, Cleveland, OH, USA.
Guy MaddernDepartment of Surgery, Adelaide University, The Queen Elizabeth Hospital, Adelaide, SA, Australia.
Rodolfo J OviedoDepartment of Surgery, Nacogdoches Medical Center, Nacogdoches, TX, USA.
Muhammed ElhadiDepartment of Surgery, Houston Methodist Hospital, Houston, TX, USA.
Ali KchaouDepartment of Surgery, Sfax Medical School, Sfax, Tunisia.
Saamia ShaikhDepartment of Surgery, Penn State Health Milton S. Hershey Medical Center, Hershey, PA, USA.
Felipe B MaegawaDepartment of Surgery, Emory University, Atlanta, GA, USA.
Andrew CatanzaroDivision of Gastroenterology, University Hospitals of Cleveland, Cleveland, OH, USA.
Richard D Shlansky-GoldbergDivision of Interventional Radiology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, USA.
Sean ClearyDivision of General Surgery, UHN-Toronto General Hospital, University of Toronto, Toronto, ON, Canada.
Ivan D FlorezDepartment of Pediatrics, University of Antioquia, Medellin, Colombia.
Kevin El-HayekDepartment of Surgery, The MetroHealth System, Case Western Reserve University School of Medicine, Cleveland, OH, USA.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundWalled-off pancreatic necrosis (WOPN) is a serious sequela following acute pancreatitis with significant associated morbidity and mortality. These guidelines provide best practice recommendations for the management of this complication. METHODOLOGY: A systematic review was conducted, including a literature search from 1/1/2020 to 1/24/2025, addressing four key questions regarding the management of WOPN in adults. The findings were subsequently presented to a multidisciplinary panel of surgeons, gastroenterologists, and interventional radiologists, including those from both the Society of American Gastrointestinal and Endoscopic Surgeons (SAGES) and the Americas Hepato-Pancreato-Biliary Association (AHPBA). The GRADE methodology was then used to develop evidence-based recommendations.

resultsAll recommendations were based on very low certainty of evidence. A conditional recommendation was made for endoscopic management versus image-guided intervention. A conditional recommendation was made for image-guided intervention versus open surgery. A conditional recommendation was made for either minimally invasive surgery or image-guided intervention. A conditional recommendation was made for minimally invasive surgery versus endoscopic intervention. A conditional recommendation was made for either a pure endoscopic approach versus a step-up approach.

conclusionsThese recommendations provide guidance for the approach to the management of WOPN according to the existing literature and expert input. The panel also highlighted evidence gaps to support future research for a stronger evidence base regarding the treatment of WOPN.

Indexed as

Pancreatitis, Acute NecrotizingDrainageHumansMinimally Invasive Surgical ProceduresCystenterostomyEndoscopyGuidelineInterventional radiologyNecrosectomyNecrotizing pancreatitisWalled-off pancreatic necrosis

Identifiers

PMID42675307

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.