Evidence map›Paper›PMID 42675291›Full record

Observational studyArchives of gynecology and obstetrics2026

High prevalence of magnesium supplementation during pregnancy: results from the LIFE Child study.

Martina P Neininger, Sophie U J Bremer, Anne Dathan-Stumpf, Holger Stepan, Wieland Kiess, Astrid Bertsche, Mandy Vogel, Thilo Bertsche

Registry-linked trialAbstract readObservational Study
In one paragraph

Observational study in Archives of gynecology and obstetrics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02550236 (Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases), which is not on this map. Not yet cited in PubMed.

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0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02550236 recruitingnot on this map

Prospective Population-based Childhood Cohort Study in the Leipzig Area Investigating Genetic, Environmental, and Metabolic Factors and Their Association With the Development of Civilization Diseases

TypeobservationalSponsorUniversity of LeipzigRan2010 to 2026Enrolled7,000ConditionsChild Development
3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Martina P Neininger *Drug Safety Centre, Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University Hospital and Leipzig University, Leipzig University, Bruederstrasse 32, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0002-5208-0888
Sophie U J Bremer *Drug Safety Centre, Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University Hospital and Leipzig University, Leipzig University, Bruederstrasse 32, 04103, Leipzig, Germany.ORCID http://orcid.org/0000-0002-9536-6878
Anne Dathan-StumpfDepartment of Obstetrics, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4331-6569
Holger StepanDepartment of Obstetrics, University Hospital Leipzig, Leipzig, Germany.ORCID http://orcid.org/0000-0003-1264-7365
Wieland KiessLIFE Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0003-4118-9455
Astrid BertscheCenter for Children and Adolescents, Department of Neuropediatrics, University Medicine Greifswald, Greifswald, Germany.ORCID http://orcid.org/0000-0003-2832-0156
Mandy Vogel *LIFE Leipzig Research Centre for Civilization Diseases, Leipzig University, Leipzig, Germany.ORCID http://orcid.org/0000-0003-2051-1249
Thilo Bertsche *Drug Safety Centre, Clinical Pharmacy, Institute of Pharmacy, Medical Faculty, Leipzig University Hospital and Leipzig University, Leipzig University, Bruederstrasse 32, 04103, Leipzig, Germany. thilo.bertsche@uni-leipzig.de.ORCID http://orcid.org/0000-0002-4930-6655

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeWe examined the prevalence of magnesium supplementation among pregnant women in Germany and assessed whether risk factors for preterm birth might be associated with magnesium use. We explored the association between magnesium supplementation and pregnancy duration .

methodsThe LIFE Child Study (Leipzig, Germany) recruited pregnant women and collected data in the 24

resultsDuring their current pregnancy, 60.0% (647/1078) of the women supplemented mono-magnesium, and 70.8% (763/1078) supplemented magnesium through mono- and/or combination preparations (overall magnesium). In 215 women, information on physicians' recommendations/prescriptions was collected: In 84.2% (181/215) of those women, a physician prescribed (104/215, 48.4%) or recommended (77/215, 35.8%) the mono-magnesium supplement. Increasing age was positively associated with magnesium supplementation with overall magnesium use increasing from 57.8% at age 20 years to 84.3% at age 45. Women with medium (OR 2.93; 95% CI 1.20-7.37) or high SES (OR 3.82; 95% CI 1.54-9.77) were more likely to supplement overall magnesium than women with low SES. Mono-magnesium supplementation was more likely in women with premature contractions (OR 2.97; 95% CI 1.36-7.47) with a still positive but not significant effect for overall magnesium (OR = 1.78, 95% CI 0.81-4.49). Magnesium supplementation did not affect pregnancy duration.

conclusionMagnesium supplementation during pregnancy is widespread. Increasing age, higher SES, and premature contractions seem to have the potential to influence magnesium supplementation during pregnancy.

trial registrationLIFE Child is registered under the trial number: NCT02550236.

Indexed as

Dietary SupplementsMagnesiumPremature BirthAdultFemaleGermanyHumansPregnancyPrevalenceProspective StudiesRisk FactorsYoung AdultMagnesiumMagnesiumPregnancyPregnancy cohortPremature contractionsSupplementation

Identifiers

PMID42675291
PMCPMC13529859

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