Evidence map›Paper›PMID 42675290›Full record

ArticleInternational journal of computer assisted radiology and surgery2026

Virtual intraoperative CT (viCT): sequential anatomic updates for modeling tissue resection throughout endoscopic sinus surgery.

Nicole M Gunderson, Graham J Harris, Jeremy S Ruthberg, Pengcheng Chen, Di Mao, Randall A Bly, Waleed M Abuzeid, Eric J Seibel

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Article in International journal of computer assisted radiology and surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Nicole M GundersonDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.ORCID http://orcid.org/0000-0003-1572-0273
Graham J HarrisDepartment of Otolaryngology-Head and Neck Surgery, University of Washington Medical Center, University of Washington, Seattle, WA, USA.
Jeremy S RuthbergDepartment of Otolaryngology-Head and Neck Surgery, University of Washington Medical Center, University of Washington, Seattle, WA, USA.
Pengcheng ChenDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.
Di MaoDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA.
Randall A BlyDepartment of Otolaryngology-Head and Neck Surgery, University of Washington Medical Center, University of Washington, Seattle, WA, USA.
Waleed M AbuzeidDepartment of Otolaryngology-Head and Neck Surgery, University of Washington Medical Center, University of Washington, Seattle, WA, USA.
Eric J SeibelDepartment of Mechanical Engineering, University of Washington, Seattle, WA, USA. eseibel@uw.edu.

Funding

National Institute of Health (NIH) R25‑DC021791NIBIB NIH HHS 1R01EB039035-01
6 · The paper itself

Abstract

purposeIncomplete dissection is a common cause of persistent disease and revision endoscopic sinus surgery (ESS) in chronic rhinosinusitis. Current image-guided surgery systems typically reference static preoperative CT (pCT) and do not model evolving resection boundaries. We present Virtual Intraoperative CT (viCT), a method for sequentially updating pCT throughout ESS using intraoperative 3D reconstructions from monocular endoscopic video to enable visualization of evolving anatomy in CT format.

methodsMonocular endoscopic video is processed using a depth-supervised NeRF framework with virtual stereo synthesis to generate metrically scaled 3D reconstructions at multiple surgical intervals. Reconstructions undergo rigid, landmark-based registration in 3D Slicer guided by anatomical correspondences and are then voxelized into the pCT grid. viCT volumes were generated using a ray-based voxel occupancy comparison between pCT and reconstruction to delete outdated voxels and remap preserved anatomy and updated boundaries. Performance is evaluated in a cadaveric feasibility study of four specimens across four ESS stages using volumetric overlap (DSC and Jaccard) and surface metrics (HD95, Chamfer, MSD, and RMSD), alongside qualitative slice comparisons with ground-truth interval CT.

resultsviCT updates show high volumetric agreement and submillimeter mean global surface error. The Dice Similarity Coefficient was

conclusionviCT enables CT-format, sequential anatomic updating in an ESS setting without external tracking or additional intraoperative imaging. Future work will focus on fully automating registration, expanding validation in live cases, and optimizing runtime for intraoperative deployment.

Indexed as

Endoscopic sinus surgeryImage-guided surgeryIntraoperative imagingNeural radiance fieldsSurgical navigationThree-dimensional reconstruction

Identifiers

PMID42675290

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.