Evidence map›Paper›PMID 42675186›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2026

Redefining neonatal thrombocytopenia: an evidence-based approach, improved by the refineR algorithm.

Bailey B Zeiler, Timothy M Bahr, Kelly Doyle, Erick Henry, Lindsey C Carlson, Patricia Davenport, Martha C Sola-Visner, Robin K Ohls, Robert D Christensen

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Article in Journal of perinatology : official journal of the California Perinatal Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Bailey B ZeilerDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA. bailey.zeiler@hsc.utah.edu.ORCID http://orcid.org/0009-0007-6820-0710
Timothy M BahrDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-7946-0290
Kelly DoyleDepartment of Pathology, University of Utah Health, and ARUP Laboratories, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0002-2019-9112
Erick HenryObstetric and Neonatal Clinical Programs and Analytics, Intermountain Health, Murray, UT, USA.
Lindsey C CarlsonWomen and Newborns Research, Intermountain Health, Murray, UT, USA.
Patricia DavenportDivision of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0003-1230-504X
Martha C Sola-VisnerDivision of Newborn Medicine, Boston Children's Hospital and Harvard Medical School, Boston, MA, USA.ORCID http://orcid.org/0000-0002-0013-598X
Robin K OhlsDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0003-2865-8878
Robert D ChristensenDivision of Neonatology, Department of Pediatrics, University of Utah, Salt Lake City, UT, USA.ORCID http://orcid.org/0000-0001-5872-582X

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveA common definition of neonatal thrombocytopenia is a platelet count <150,000/µL. The international hematologic consensus designation of cytopenia is a blood count <2.5th percentile lower reference interval for an appropriate comparison population. We hypothesized that a new reference interval modeling algorithm, refineR, would generate more accurate platelet reference intervals and, therefore, more accurate and evidence-based definitions of neonatal thrombocytopenia. STUDY

designWe utilized refineR to analyze platelet counts from large clinical databases to generate new neonatal platelet reference intervals.

resultsWith 155,062 neonatal platelet counts, we created reference intervals for the day of birth and over the first 30 days. These included a lower (2.5th percentile) reference interval at birth for neonates ≥34 weeks of 119,600 platelets/µL (95% CI, 117,700 to 135,300/µL) and for neonates <34 weeks of 103,000 platelets/µL (98,700 to 105,600).

conclusionPlatelet counts of neonates at birth in the range of 120,000-150,000/µL are normal.

Identifiers

PMID42675186

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.