ArticleScientific reports2026
Analysis of medication adherence and its influencing factors in outpatients with mental disorders: a mixed study in eastern of China.
Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundMedication adherence is critical for outpatients with mental disorders, yet previous research in China has relied predominantly on quantitative surveys that have overlooked experiential and contextual factors.
objectiveThis mixed-methods study quantified adherence levels and associated factors, while exploring patients' and caregivers' perceived barriers and facilitators.
resultsA total of 546 valid responses were collected (294 male, 252 female; age range 18-87 years). The sample comprised 357 (65.4%) patients with depression/anxiety, 126 (23.1%) with schizophrenia, and 63 (11.5%) with bipolar disorder. Moderate-to-high adherence (MMAS-8 score ≥ 6) was observed in 73.1% of patients. Medication adherence showed significant overall associations with education level (χ
conclusionsEducation level and disease duration are the most robust independent predictors of medication adherence in this population. Qualitative findings complement this by revealing that family support quality, stigma, and therapeutic alliance-though not captured as independent factors in the conservative statistical model-constitute essential process-level determinants that static variables fail to capture. Interventions should combine targeted health education for low-education and early-stage patients with family-based psychosocial support, stigma reduction campaigns, and shared decision-making to address both structural and relational barriers to adherence.
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